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Diss Factsheets
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EC number: 201-202-3 | CAS number: 79-39-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Dermal absorption
Administrative data
- Endpoint:
- dermal absorption, other
- Remarks:
- in silico prediction
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
- Reference Type:
- publication
- Title:
- Handbook of Toxicology, Third Edition
- Author:
- Derelanko MJ, Auletta CS
- Year:
- 2 014
- Bibliographic source:
- CRC Press, Taylor and Francis Group, Handbook of Toxicolocy, General Toxocology, Body Wieght/Surface Area Conversion Tables 2.22 and 2.23, page 81
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
Test material
- Reference substance name:
- Methacrylamide
- EC Number:
- 201-202-3
- EC Name:
- Methacrylamide
- Cas Number:
- 79-39-0
- Molecular formula:
- C4H7NO
- IUPAC Name:
- methacrylamide
Constituent 1
- Specific details on test material used for the study:
- SMILES structure: CC(=C)C(N)=O
Test animals
- Species:
- rat
Results and discussion
Percutaneous absorption
- Remarks on result:
- other: a moderate relative dermal absorption was calculated
Any other information on results incl. tables
Calculation of dermal absorption of methacrylamide in rats under the conditions of test guideline OECD 402, Acute dermal toxicity in rats:
Heylings at al have established an in silico model to predict dermal absorption of methacrylates and methacrylamides. This model is based onestablished model (Potts and Guy, 1992), using data derived with human epidermal membranes.
QSARs, when applied to estimating dermal permeability coefficients, are sometimes known as quantitative structure-permeability relationships (QSPeRs or QSPRs). Descriptors such as hydrophobicity, molecular size, and possibility of hydrogen bonding (which may describe non-covalent interactions with skin proteins) are important for the development of QSARs.
QSPeRs are statistically-derived linear and non-linear relationships between the steady-state permeability of a compound, usually measured from water, and various physicochemical descriptors and/or structural properties of the molecule. Typically, the main input parameter is the octanol:water partition coefficient. The dermal absorption measurement that has been most commonly used in QSAR modelling is the permeability coefficient Kp,because it characterises the steady-state permeation rate of a chemical from a specific vehicle through a given membrane. Although Kpis not directly suitable for application in risk assessment, it can be used in conjunction with measured (or estimated) solubility in the same vehicle (e.g. water) to predict a maximum flux through the skin.
Potts RO and Guy RH (1992). Predicting Skin Permeability. Pharm. Res. 9(5): 663-669.
No. |
Chemical Class |
Test Chemical / Compound Identity |
Acronym |
Molecular Weight |
Log P |
Predicted Flux (μg/cm2/h) |
Relative Dermal Absorption |
33 |
Methacrylamides-tier 1 |
Methacrylamide |
MAA |
85.1 |
-0.15 |
42.625 |
Moderate |
Parameters for prediction of dermal absorption in rats:
Surface of the body for application of test substance: not less than 10 % (OECD 402)
Exposure time: 24 hours (OECD 402)
Representative body weight rat: 0.15 kg (Handbook of Toxicology)
Representative surface area rat: 0.025 m² (Handbook of Toxicology)
Calculation:
10 % body surface of a rat correspond to 25 cm²
Absorption of methacrylamide in 1 rat under the conditions of OECD 402:
42.625 µg/cm²/h x 25 cm² x 24 h = 25.577 mg/150 g
25.277 mg/150 g correspond to 170.5 mg/kg
The maximum absorption of methacrylamide in rats under the conditions of OECD 402 is 170.5 mg/kg
Applicant's summary and conclusion
- Conclusions:
- The maximum dermal absorption of methacrylamide under the condtions of an acute dermal toxicity test acc. OECD 402 was calculated based on QSAR predictions by Heylings et al. An absorption of 170.5 mg/kg bw in maximum in rats was predicted.
- Executive summary:
A predicted dermal flux of 42.625 µg/cm2/h was calculated, indicative for a moderate relative dermal absorption.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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