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Registration Dossier
Diss Factsheets
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EC number: 201-766-0 | CAS number: 87-69-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- other: data sharing dispute
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: data sharing dispute
Data source
Reference
- Reference Type:
- other: not specified
- Title:
- Metabolism of L (+) - and D (-) - tartaric acids in different animal species
- Author:
- Gry J & Larsen JG
- Year:
- 1 978
- Bibliographic source:
- N.A.
Materials and methods
- Principles of method if other than guideline:
- data sharing dispute
Test material
- Reference substance name:
- (+)-tartaric acid
- IUPAC Name:
- (+)-tartaric acid
Constituent 1
Results and discussion
Main ADME resultsopen allclose all
- Type:
- excretion
- Results:
- rats and guinea pigs handle the compound in different ways, the pig held an intermediate position in the ability to excrete the tartaric acids.
- Type:
- excretion
- Results:
- only in the rat was there a difference in the ability to excrete the two isomers, with a lower recovery of the D(-)-form.
- Type:
- metabolism
- Results:
- the in vitro study showed that no difference of decomposition of tartaric acid by the intestinal flora between guinea pig and rat.
Applicant's summary and conclusion
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