Registration Dossier
Registration Dossier
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EC number: 200-898-6 | CAS number: 75-75-2
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets generally accepted scientific standards, acceptable for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Alkylating Esters VII. The metabolism of iso-propyl-methanesulphonate and iso-propyl iodide in the rat.
- Author:
- Jones AR, Edwards K
- Year:
- 1 973
- Bibliographic source:
- Experientia 29(5): 538-539
- Report date:
- 1973
Materials and methods
- Objective of study:
- excretion
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Excretion of radioactivity over 24 h in the urine from rats administered i.p. with 35S-methanesulphonic acid was measured. The activity was expressed as percent of the administered dose.
- GLP compliance:
- no
Test material
- Reference substance name:
- Methanesulphonic acid
- EC Number:
- 200-898-6
- EC Name:
- Methanesulphonic acid
- Cas Number:
- 75-75-2
- Molecular formula:
- CH4O3S
- IUPAC Name:
- methanesulfonic acid
- Details on test material:
- - Name of test material (as cited in study report): 35S-methanesulphonic acid
- Physical state: aqueous solution
- Analytical purity: not reported
- Radiochemical purity (if radiolabelling): not reported
- Specific activity (if radiolabelling): not reported
- Locations of the label (if radiolabelling): S
- Expiration date of radiochemical substance (if radiolabelling): not reported
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- 35 S
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Duration and frequency of treatment / exposure:
- single administration
Doses / concentrations
- Remarks:
- Doses / Concentrations:
50 mg/kg bw
- No. of animals per sex per dose / concentration:
- not reported
- Control animals:
- yes
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on excretion:
- Excretion of radioactivity derived from 35S-methanesulphonic acid via the urine: 100 %.
Metabolite characterisation studies
- Metabolites identified:
- no
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
