Registration Dossier
Registration Dossier
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EC number: 201-837-6 | CAS number: 88-51-7
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: publication not sufficient for full methodological assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Guideline:
- other: detailed description of methodology not published
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-amino-6-chlorotoluene-3-sulphonic acid
- EC Number:
- 201-837-6
- EC Name:
- 4-amino-6-chlorotoluene-3-sulphonic acid
- Cas Number:
- 88-51-7
- Molecular formula:
- C7H8ClNO3S
- IUPAC Name:
- 2-amino-4-chloro-5-methylbenzene-1-sulfonic acid
- Test material form:
- other: particles suspended in an air stream
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- nose only
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- gravimetric analsysis at 1/2 hour intervals during each exposure, particle size properties determined during each exposure
- Duration of exposure:
- 4 h
- Remarks on duration:
- single exposure time for each of 3 group
- Concentrations:
- 1. 1st group of 6 rats: range 2.2 - 11 mg/l, mean 4.8 mg/l, standard deviation 3.1 mg/l; particle size 73% respirable, mass median diameter 2.0µ
2. 2nd group of 6 rats: range 1.7 - 21 mg/l, mean 12 mg/l, standard deviation 7.4 mg/l; particle size 45% respirable, mass median diameter 5.0µ
3. 3rd group of 6 rats: range 5 - 18 mg/l, mean 13 mg/l, standard deviation 3.8 mg/l, particle size 60% respirable, mass median diameter 8.3µ
Results and discussion
Effect levels
- Remarks on result:
- other: Lethal concentration not assignable since none of the rats of each group showed a lethal reaction at a concentration of 13 mg/l, the highest possible concentration generated under the experimental conditions
- Mortality:
- none of the rats of each group showed a lethal reaction at a concentration of 13 mg/l, the highest possible mean concentration generated under the experimental conditions
- Body weight:
- slight initial weight loss followed by gain of weight
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: other: Interpretation of literature data
- Conclusions:
- The NOAEL of 13 mg/l is above the threshold for classification according to Regulation (EC) no. 1272/2008, Directive 67/548/EEC respectively. Hence the substance is not needed to be classified.
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