Registration Dossier
Registration Dossier
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EC number: 201-837-6 | CAS number: 88-51-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: publication not sufficient for full methodological assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Guideline:
- other: detailed description of methodology not published
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-amino-6-chlorotoluene-3-sulphonic acid
- EC Number:
- 201-837-6
- EC Name:
- 4-amino-6-chlorotoluene-3-sulphonic acid
- Cas Number:
- 88-51-7
- Molecular formula:
- C7H8ClNO3S
- IUPAC Name:
- 2-amino-4-chloro-5-methylbenzene-1-sulfonic acid
- Test material form:
- other: test sample undiluted and moistened with saline
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: albino
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- physiological saline
- Controls:
- not specified
- Duration of treatment / exposure:
- ca. 24 hours
- Observation period:
- 24 hours and 48 hours
- Number of animals:
- 6
Results and discussion
Any other information on results incl. tables
3 of 6 animals exhibited slight to mild erythema and no animal exhibited edema at 24 h after exposure. At 48 h after exposure one animal exhibited light erythema. No information about reversibility is given.
Applicant's summary and conclusion
- Interpretation of results:
- other: mildly skin irritating
- Remarks:
- Criteria used for interpretation of results: expert judgment
- Conclusions:
- Since less than 4 of 6 animals exhibited mild to slight erythema, no edema for all 6 animals the substance does not need to be classified according to Regulation (EC) no. 1272/2008, Directive 67/548/EEC respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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