Registration Dossier
Registration Dossier
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EC number: 215-721-8 | CAS number: 1345-25-1
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Short report - original language Russian. Iron(II)Oxide belongs to the iron oxides family and presents comparable physico chemical properties, leading to similar behaviour for the all members of the iron oxide substances. In particular, based on affinity of the chemical structure, Iron Oxide (Fe3O4) and Iron(III)Oxide (Fe2O3) are selected to support read across for the Iron(II)Oxide dossier. Full justification paper is provided in the current Summary Section.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 976
Materials and methods
- Principles of method if other than guideline:
- Type: other: reproduction in the course of a chronic toxicity study
Method: other: application of magnetite as a 50% suspension in sunflower oil - GLP compliance:
- no
- Type of method:
- in vivo
Test material
- Reference substance name:
- Triiron tetraoxide
- EC Number:
- 215-277-5
- EC Name:
- Triiron tetraoxide
- Cas Number:
- 1317-61-9
- Molecular formula:
- Fe3O4
- IUPAC Name:
- Magnetite
- Details on test material:
- IUCLID4 Test substance: other TS: Magnetite (no data on purity)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sunflower oil
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 6 weeks
- Frequency of treatment:
- weekly
Doses / concentrations
- Remarks:
- Doses / Concentrations:
20 000 mg/kg
Basis:
- Control animals:
- yes
- Details on study design:
- Duration of test: 1 year
Results and discussion
Observed effects
Applicant's summary and conclusion
- Executive summary:
- no effects of the treatment were detected regarding number and development of offspring
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
