Registration Dossier
Registration Dossier
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EC number: 215-721-8 | CAS number: 1345-25-1
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Main features of study reported; non standard test, conducted on iron particles (read across from iron Oxide category). Iron(II)Oxide belongs to the iron oxides family and presents comparable physico chemical properties, leading to similar behaviour for the all members of the iron oxide substances. In particular, based on affinity of the chemical structure, Iron Oxide (Fe3O4) and Iron(III)Oxide (Fe2O3) are selected to support read across for the Iron(II)Oxide dossier. Full justification paper is provided in the current Summary Section.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
Materials and methods
- Principles of method if other than guideline:
- Animals were exposed for 1 to 2 hours to iron oxide particles in an plethysmograph and lung functional parameters determined: Resistance, compliance, tidal volume, frequency, minute volume Particle size: 0.03 < x < 0.3 µm geometric mean diameter: 0.076 µm
- GLP compliance:
- no
- Test type:
- other: measurement of the mechanical behaviour of the lung
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- other TS: Iron oxide fume produced from combustion of iron pentacarbonyl (Fe2O3)
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: fume
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: unchanged (no vehicle)
- Analytical verification of test atmosphere concentrations:
- not specified
- Remarks on duration:
- no data
- Concentrations:
- 7 mg/m³
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Any other information on results incl. tables
Inhalation of iron oxide fume (concentration 7 mg/m³ - mainly Fe2O3) did not produce any detectable effect
Applicant's summary and conclusion
- Executive summary:
- Animals were exposed for 1 to 2 hours to iron oxide particles in an plethysmograph
and lung functional parameters determined. As a result inhalation of iron oxide
fume did not produce any detectable effects.
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