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EC number: 252-161-3
CAS number: 34708-08-2
OECD TG 211 test proposal
There are no data available with the
registered substance triethoxy(3-thiocyanatopropyl)silane, CAS
34708-08-2. Therefore a long-term toxicity to aquatic invertebrates
study OECD TG 211 is proposed.
A long-term toxicity to
invertebrates study is proposed because the short-term aquatic
invertebrate data determined a 24 hour EC50 value of 29 mg/L,
which represents a similar magnitude of short-term toxicity obtained
with the fish study, where an LC50 value in the range 10 to
18 mg/L was determined. Therefore, taking into consideration animal
welfare and the objective to reduce testing with vertebrates, it is
proposed to conduct a long-term aquatic toxicity study with
invertebrates rather than with fish. It
is additionally proposed to conduct a Dose Range Finding (DRF) study
during the OECD TG 211, the results of which will be compared with the
available short-term toxicity to invertebrates study to determine the
most appropriate concentration range, and with the short-term toxicity
to fish study to confirm the most sensitive trophic level.
In the meantime, a PNEC has been
derived for the purpose of chemical safety assessment using the lowest
EC/LC50 value in the short-term aquatic toxicity studies,
which in this case is a conservative 96 hour 10 mg/l with fish. An
assessment factor of 1000 was applied to derive the freshwater PNEC
using the short-term fish result.
Details on how the PNEC and the risk characterisation ratios have been
derived can be found in IUCLID Section 6.0 and Chapters 9 and 10 of the
Chemical Safety Report, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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