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EC number: 235-935-5
CAS number: 13052-09-0
The registered substance is not irritating
to skin and eyes.
Justification for selection of skin irritation / corrosion endpoint:
K1:The study is performed according to OECD guidelines and GLP.
Justification for selection of eye irritation endpoint:
of dermal lesions (following 4-h application) on intact skin
Days after application
Mean score erythema
Mean score oedema
The potential the substance to cause
inflammatory or corrosive changes upon first contact with skin was
assessed by semi-occluded application of 0.5 ml of the test material to
the closely-clipped dorsa of three New Zealand White rabbits for four
hours. Dermal reactions were assessed 1, 24, 48 and 72 hours and six and
nine days after removal of the dressings. Very slight erythema was
observed in all rabbits during the first 24 hours after bandage removal,
continuing in two rabbits up to the 72 hour examination.
Residual dose material adhered to the test
site for up to six days. The test sites of all animals were overtly
normal by Day 9. The test substance is not irritating to skin.
Rabbit No and sex
Region of the eye
Hours after instillation
Average 24-48-72 hours
Degree of opacity
The potential to cause damage to the
conjunctiva, iris or cornea was assessed in three New Zealand White
rabbits, each subjected to a single ocular instillation of 0.1 ml of the
test material. Ocular reactions were assessed 1, 24, 48 and 72 hours
after treatment. Injection of the conjunctival blood vessels was
observed in all rabbits during the first hour following instillation.
Very slight discharge and very slight chemosis were also observed in two
of these rabbits at this time. The test eyes of all rabbits were overtly
normal at the 24 hour examination. Instillation of the test material
caused practically no initial pain response.
Based on the results an in vivo skin and eye
irritation study in rabbits, the data is conclusive but not sufficient
for classification for these endpoints.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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