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EC number: 939-967-7
CAS number: -
Disintegrations per Minute, Disintegrations per Minute/Node and
Concentration (% w/w) in propylene glycol
* Disintegrations per
minute/node obtained by dividing the disintegrations per minute value by
8 (the total number of lymph nodes).
Observations and Mortality Data
There were no deaths.
No signs of systemic toxicity were noted in the test or control animals
during the study.
Bodyweight changes of
the test animals between Day 1 and Day 6 were comparable to those
observed in the corresponding control group animals over the same period.
The potential of the test material to act as a sensitiser was
investigated in accordance with the standardised guidelines OECD 429 and
EU Method B.42.
The study assessed the skin sensitisation potential of the test material
in female mice of the CBA/Ca strain following topical application to the
dorsal surface of the ear. Three groups, each of four animals, were
treated with 50 µL (25 µL per ear) of the test material as a suspension
in propylene glycol at concentrations of 50, 25 and 10 % w/w. A further
group of four animals was treated with propylene glycol alone. A
concurrent positive control test, using a group of four animals, was
performed with phenylacetaldehyde, at a concentration of 2.5 % v/v in
The results for all three concentrations of the test material were
negative, whilst the positive control material gave the expected result.
Therefore, the test material was considered to be a non-sensitiser under
the conditions of this study in accordance with EU criteria.
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