Registration Dossier
Registration Dossier
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EC number: 922-551-4 | CAS number: 1187440-66-9
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
A calculation method prediction was performed to assess the chronic toxicity of the test item to fish, using the WAF method. This calculation method predicts the endpoint value which would be expected when testing the substance under experimental conditions in a laboratory following the Guideline for Testing of Chemicals No. 210, "Fish, Early-life Stage Toxicity Test" (OECD, 2013), adapted for testing of a mixture using the WAF method.
The criterion predicted was the median lethal loading rate of the mixture EL10 (10% Effective Loading), a statistically derived loading rate which is expected to cause an effect of 10% on growth or reproducibility of test animals within a period of 32 days.
The chronic toxicity to fish was determined using a calculation method for the Mechanism of Action (MechoA) in question (MechoA 1.1 & 2.1, both related to non-polar narcosis) (Bauer et al., 2018). This method has previously been validated in an internal publication for acute exposure of non-polar narcosis compounds (Bicherel and Thomas, 2014). The calculation method used individual toxicity values which were predicted using QSAR models validated to be compliant with the OECD recommandations for QSAR modeling (OECD, 2004, 2007).
Results: Since no chronic toxic effect is expected from each constituent of the mixture which are considered within this approach, the final toxicity result for the test item is expected to be greater than the solubility limit.
Time (32 d) EL10 (mg test item.L-1) > solubility limit
Key value for chemical safety assessment
Additional information
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