Alcohols, C20-22, reaction products with phosphorus oxide (P2O5)

Hydrolysis

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Administrative data

Endpoint:

hydrolysis

Type of information:

experimental study

Adequacy of study:

key study

Study period:

17 September 2008 to 01 October 2008

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2008

Materials and methods

Principles of method if other than guideline:

- Principle of test:
The hydrolysis as a function of pH of the test material has been assessed.The methodology assessed was found in the current OECD Guidelines for Testing of Chemicals.

Testing was not carried out according to Method 111 of the OECD Guidelines for Testing of Chemicals, 13 April 2004 for the following reasons:
The test material is a complex mixture and the hydrolysis guidelines are not suitable for assessment of mixtures. Injections of test material in tetrahydrofuran:water (90:10 v/v) on an Agilent 1200 LC-MS with electrospray in negative mode confirmed the presence of a complex composition and was unable to identify the individual components.

GLP compliance:

no

Test material

Test material information

Constituent 1

Details on test material:

Description : white flakes
Batch numbers : T71241 and T80821
Storage conditions : room temperature in the dark

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Batch numbers: T71241 and T80821

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: The test item was stored at room temperature in the dark

Results and discussion

Preliminary study:

Due to low solubility in aqueous media, assessment of hydrolytic stability was not carried out using Method 111 of the OECD Guidelines.

Test performance:

Functional groups of the substance are an alkyl phosphate ester and alcohol. The alcohol group, being part of a C20/C22 fatty alcohol, would not be expected to hydrolyse under the test method parameters of pH 4 to pH 9. The fatty alcohol accounts for 40 % to 50 % of the test material composition.
The phosphate ester group occurs in the mono-ester and a di-ester which have C20/C22 alkyl chains from the fatty alcohol. The esters account for 50 % to 60 % of the test material composition. Phosphate esters will hydrolyse in aqueous media, although hydrolysis of the test material may be minimal in the pH range of 4 to 9 and at 25 °C due to the low solubility of the individual components and possible formation of micelles, as the structures are typical of that of a surfactant. These would possibly aid stability as attack would be stearically hindered by the proximity of grouped molecules. No estimated rates of hydrolysis could be sourced from available literature sources.

Transformation products:

not measured

Dissipation DT50 of parent compound

Key result

Remarks on result:

not determinable because of methodological limitations

Any other information on results incl. tables

Testing was not carried out according to Method 111 of the OECD Guidelines for Testing of Chemicals, 13 April 2004 for the following reasons:

The test material is a complex mixture and the hydrolysis guidelines are not suitable for assessment of mixtures. Injections of test material in tetrahydrofuran:water (90:10 v/v) on an Agilent 1200 LC-MS with electrospray in negative mode confirmed the presence of a complex composition and was unable to identify the individual components.

The alcohol group would not be expected to hydrolyse under the test method parameters of PH 4 to PH 9.

Phosphate esters will hydrolyse in aqueous media.

Applicant's summary and conclusion

Conclusions:

The alcohol group would not be expected to hydrolyse under the test method parameters of PH 4 to PH 9.
Phosphate esters will hydrolyse in aqueous media.

Executive summary:

Testing was not carried out according to Method 111 of the OECD Guidelines for Testing of Chemicals, 13 April 2004 for the following reasons:

The test material is a complex mixture and the hydrolysis guidelines are not suitable for assessment of mixtures. Injections of test material in tetrahydrofuran:water (90:10 v/v) on an Agilent 1200 LC-MS with electrospray in negative mode confirmed the presence of a complex composition and was unable to identify the individual components.

The alcohol group would not be expected to hydrolyse under the test method parameters of PH 4 to PH 9.

Phosphate esters will hydrolyse in aqueous media.