Registration Dossier
Registration Dossier
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EC number: 239-743-2 | CAS number: 15667-63-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- 1981
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- 1-cyanoallyl acetate
- EC Number:
- 239-743-2
- EC Name:
- 1-cyanoallyl acetate
- Cas Number:
- 15667-63-7
- Molecular formula:
- C6H7NO2
- IUPAC Name:
- 1-cyanoprop-2-en-1-yl acetate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Savo, Ivanovas Kisslegg
- Fasting period before study: on test day
- Housing: individually
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: > 5 days
ENVIRONMENTAL CONDITIONS
according to guideline
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
according to guideline
REMOVAL OF TEST SUBSTANCE
- Washing: yes
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.00681-0.0681 mL/kg (males), 0.0147-0.0681 mL/kg (females)
- Constant concentration used: yes
- Duration of exposure:
- 24 h
- Doses:
- 6.95-69.5 mg/kg bw (males)
15.0-69.5 mg/kg bw (females) - No. of animals per sex per dose:
- 2-3
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- Probit Analysis
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 6.95 - < 15 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 32.2 mg/kg bw
- Mortality:
- Deaths occurred between 30 min and 2 h after application.
- Clinical signs:
- other: decrease of muscle tone, general loss of reflexes, streneous respiration, cyanosis, mydriasis. First symptoms 3-40 min post appl. persistant 2 to 3 h.
- Gross pathology:
- no substance related changes
- Other findings:
- formation of eschar at the exposed skin site; severe local reactions: nose bleedings, redness and crusts
Any other information on results incl. tables
The test substance was applied undiluted and caused severe local reactions (nose bleedings, redness and crusts) in addition to the systemic toxicity.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 based on GHS criteria
- Remarks:
- Migrated information
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