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Diss Factsheets
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EC number: 207-975-3 | CAS number: 503-74-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Stability
Phototransformation in air
For the indirect photodegradation of isovaleric acid in air by the reaction with OH-radicals, a half-life of approx. 31.3 hours (2.6 days) was calculated (GUBDH, 2012, US EPA EPI Suite v4.10).
Hydrolysis
Due to its chemical structure and reactivity, isovaleric acid will not hydrolyse under environmental conditions. The structure of the molecule does not contain hydrolysable constituents (GUBDH, 2008).
Biodegradation
Biodegradation in water: screening test
Isovaleric acid has been shown to be readily biodegradable in two tests for ready biodegradability.
1. - test similar to OECD TG 301 C (Urano, 1986; RL2; KS)
2. - test similar to OECD TG 301 D (Dias, 1971; RL2; SS)
Biodegradation in water and sediment: simulation test
Tests need not be conducted, as isovaleric acid is readily biodegradable.
In addition, data are not required as only Annex VII data requirements have to be fulfilled.
Biodegradation in soil
Tests need not be conducted, as isovaleric acid is readily biodegradable. In addition, data are not required as only Annex VII data requirements have to be fulfilled.
Bioaccumulation
Bioaccumulation: aquatic/sediment
Not required as the substance is registered under provisions of Article 12(1)(c) of REACH.
As the log Kow of isovaleric acid is low (log Kow = 1.7, Sect. 4.7, OXEA, 2010) and the substance is readily biodegradable (Urano, 1986 and Dias 1971), the potential for bioaccumulation of isovaleric acid is low.
In addition, calculated Log BCF and log BAF (upper trophic) values of 0.5 and 0.748 respectively (US EPA EPI Suite v4.10, program component BCFBAF v3.01) indicate a low potential of isovaleric acid for bioaccumulation in aquatic organisms (GUBDH, 2012).
Terrestrial
No data available (data are not required as only Annex VII data requirements have to be fulfilled).
.
Transport and Distribution
Adsorption/Desorption
In accordance with column 2 of REACH Annex VIII Nr 9.3.1, the study does not need to be conducted as the substance has a low potential for adsorption (log Kow < 3, see Sect. 4.7) and is readily biodegradable (see Sect. 5.2.1).
Based on a calculated Koc of 4.022 (log Koc = 0.6045), isovaleric acid is expected to have a high mobility in soil (GUBDH, 2012).
Henry’s Law constant
For isovaleric acid, a Henry's law constant of 8.333E-7 atm m³/mol was determined in an experimental study using equilibrium partial pressure measurements over aqueous solutions at 298.15 K (25°C) (Khan, 1992).
Calculations (GUBDH, 2012; US EPA EPI Suite v4.10) resulted in
Bond contribution method: HLC (25°C) = 1.28E-006 atm m³/mole
Group contribution method: HLC (25°C) = 9.96E-007 atm m³/mole
Isovaleric acid will volatilize from water only to a low degree.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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