Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-517-7 | CAS number: 141-98-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- SPECIES
SPECIES #
(NAME): 4 Oncorhynchus mykiss (Rainbow Trout)
AGE: NR NR
LIFE STAGE: fingerling
COMMENT: 1-10 G - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- 348 mg/L CaCO3
ALKALINITY: 203 mg/L CaCO3 - Test temperature:
- 12 0C
- pH:
- 8.6
- Dissolved oxygen:
- Saturated mg/l
- Salinity:
- SALINITY:NR
- Nominal and measured concentrations:
- TYPE VALUE RANGES STANDARD CONC (ug/L) IONCIC FRACTION
F NR 45000 TO 48 000 45000 TO 48000 ug/L NR
F NR 40000 TO 45 000 40000 TO 45000 ug/L NR - Details on test conditions:
- TEST CONDITIONS
STUDY TYPE:
MEDIA: FW (Fresh water)
LOCATION: LAB (Laboratory, indoor)
CONTROL: I (insufficient control)
EXPOSURE TYPE: S ( static)
APPLICATION FREQ.: 1 X
EXPOSURE DUR.: 96 hour(s)
STAND DUR. (D): 4 day(s
TEST CONCENTRATION
CHEM ANAL. METHOD: unmeasured
UNIT OF MEASURE: ug/L micrograms per liter
TYPE VALUE RANGES STANDARD CONC (ug/L) IONCIC FRACTION
F NR 45000 TO 48 000 45000 TO 48000 ug/L NR
F NR 40000 TO 45 000 40000 TO 45000 ug/L NR
WATER QUALITY VALUE RANGE (UNIT)
TEMPERATURE: 12 NR TO NR C
pH: 8.6 NR TO NR
HARDNESS: 348 NR TO NR mg/L CaCO3
SALINITY: NR NR TO NR
ALKALINITY: 203 NR TO NR mg/L CaCO3
CONDUCTIVITY: NR NR TO NR NR
DISSOLVED OXYGEN: SAT NR TO NR mg/l
ORGANIC CARBON (NR): NR NR TO NR NR - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 40 - < 45 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Under the conditions of the present test O-isopropyl ethylthiocarbamate induced no mortality in Oncorhynchus mykiss (Rainbow Trout) below 8 mg/l (NOEC). One of the 96h-LC50 was between 40 and 45 mg/l
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 45 - < 48 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Under the conditions of the present test O-isopropyl ethylthiocarbamate induced no mortality in Oncorhynchus mykiss (Rainbow Trout) below 9 mg/l (NOEC). One of the 96h-LC50 was between 45 and 48 mg/l
- Details on results:
- EFFECT RESULTS
EFFECT: Mortality
TREND: NR
RESPONSE SITE:NR
% EFFECT: NR
EFFECT MEASUREMENT:Mortality
ENDPOINT
ENDPOINT: Lethal concentration to 50% of test organisms
ENDPOINT ASSIGN.: X
SIGNIFICANCE: NA
LEVEL: NA
BCF Value (F): NR ( NR to NR)
GENERAL COMMENTS: LOC/NR// HARD,ALK,PH/OF DILUTION H2O// AERATED// - Validity criteria fulfilled:
- yes
- Conclusions:
- Under the conditions of the present test O-isopropyl ethylthiocarbamate induced no mortality in Oncorhynchus mykiss (Rainbow Trout) below 8 mg/l (NOEC). One of the 96h-LC50 was between 40 and 45 mg/l
- Endpoint:
- short-term toxicity to fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction: US EPA accepted QSAR method for chemicals properties assessment.
- Qualifier:
- according to guideline
- Guideline:
- other: QSAR
- Principles of method if other than guideline:
- EPI Suite v 4.1/ECOSARv1.00
- GLP compliance:
- no
- Remarks:
- not applicable to QSAR models
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- other: Fishes species
- Details on test organisms:
- no further information
- Test type:
- other: QSAR model
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- not applicable. QSAR model
- Test temperature:
- not applicable. QSAR model
- pH:
- not applicable. QSAR model
- Dissolved oxygen:
- not applicable. QSAR model
- Salinity:
- not applicable. QSAR model
- Details on test conditions:
- SMILES : O(C(=NCC)S)C(C)C
CHEM : Carbamothioic acid, ethyl-, O-(1-methylethyl) ester
CAS Number: 141-98-0
MOL FOR: C6 H13 N1 O1 S1
MOL WT : 147.24
Log Kow: 3.32 (KowWin estimate)
Wat Sol: 114.4 mg/L (WskowWin estimate) - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 7.856 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- not specified
- Details on results:
- Using the EPIWIN ECOSAR QSAR model, a 96hr LC50 for freshwater fish of 7.856 mg/l was established.
Fish, 96-hr LC50 =7.856 mg/L (ppm) - Validity criteria fulfilled:
- yes
- Remarks:
- US EPA accepted QSAR method for chemicals properties assessment.
- Conclusions:
- Using the EPIWIN ECOSAR QSAR model, a 96hr LC50 for freshwater fish of 7.856 mg/l was established.
Fish, 96-hr LC50 = 7.856 mg/L (ppm)
Fish, 96-hr (SW) LC50 = 9.881mg/L (ppm)
Fish 30-day ChV = 0.894 mg/L (ppm)
Fish (SW) 30-day ChV = 2.441mg/L (ppm
Fish, 14-dayLC50 = 8.114mg/L (ppm) - Executive summary:
The ECOSAR QSAR model predicts that the 96hr LC50 for freshwater fish would to be 7.856 mg/l therefore the substance is moderately toxic to fishes.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction: US EPA accepted QSAR method for chemicals properties assessment.
- Qualifier:
- according to guideline
- Guideline:
- other: QSAR
- Principles of method if other than guideline:
- EPI Suite v 4.1/ECOSARv1.00
- GLP compliance:
- no
- Remarks:
- not applicable to QSAR models
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- other: Fishes species
- Details on test organisms:
- no further information
- Test type:
- other: QSAR model
- Water media type:
- saltwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- not applicable. QSAR model
- Test temperature:
- not applicable. QSAR model
- pH:
- not applicable. QSAR model
- Dissolved oxygen:
- not applicable. QSAR model
- Salinity:
- not applicable. QSAR model
- Details on test conditions:
- SMILES : O(C(=NCC)S)C(C)C
CHEM : Carbamothioic acid, ethyl-, O-(1-methylethyl) ester
CAS Number: 141-98-0
MOL FOR: C6 H13 N1 O1 S1
MOL WT : 147.24
Log Kow: 3.32 (KowWin estimate)
Wat Sol: 114.4 mg/L (WskowWin estimate) - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 9.881 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- not specified
- Details on results:
- Using the EPIWIN ECOSAR QSAR model, a 96hr LC50 for marine water fish of 9.881 mg/l was established.
Fish, 96-hr LC50 =9.881 mg/L (ppm) - Validity criteria fulfilled:
- yes
- Remarks:
- US EPA accepted QSAR method for chemicals properties assessment.
- Conclusions:
- Using the EPIWIN ECOSAR QSAR model, a 96hr LC50 for marine water fish of 9.881 mg/l was established.
Fish, 96-hr LC50 = 7.856 mg/L (ppm)
Fish, 96-hr (SW) LC50 = 9.881mg/L (ppm)
Fish 30-day ChV = 0.894 mg/L (ppm)
Fish (SW) 30-day ChV = 2.441mg/L (ppm
Fish, 14-dayLC50 = 8.114mg/L (ppm) - Executive summary:
The ECOSAR QSAR model predicts that the 96hr LC50 for marine water fish would to be 9.881 mg/l therefore the substance is moderately toxic to fishes.
Referenceopen allclose all
Description of key information
Under the conditions of of the study of Fuerstenau,M.C., B.M. Wakawa, R.K. Price, and R.D. Wellik,1974 O-isopropyl ethylthiocarbamate induced no mortality in Oncorhynchus mykiss (Rainbow Trout) below 8 mg/l (NOEC). One of the 96h-LC50 was between 40 and 45 mg/l and therefore the substance is slightly toxic to fishes.
The ECOSAR QSAR model predicts that the 96hr LC50 for freshwater fish would to be 7.856 mg/l therefore the substance is moderately toxic to fishes.
The ECOSAR QSAR model predicts that the 96hr LC50 for marine water fish would to be 9.881 mg/l therefore the substance is moderately toxic to fishes.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 7.856 mg/L
Marine water fish
Marine water fish
- Effect concentration:
- 9.881 mg/L
Additional information
Under the conditions of of the study of Fuerstenau,M.C., B.M. Wakawa, R.K. Price, and R.D. Wellik,1974 O-isopropyl ethylthiocarbamate induced no mortality in Oncorhynchus mykiss (Rainbow Trout) below 8 mg/l (NOEC). One of the 96h-LC50 was between 40 and 45 mg/l and therefore the substance is slightly toxic to fishes.
The ECOSAR QSAR model predicts that the 96hr LC50 for freshwater fishwould to be7.856 mg/l therefore the substance is moderately toxic to fishes.
The ECOSAR QSAR model predicts that the 96hr LC50for marine water fishwould to be 9.881 mg/l therefore the substance is moderately toxic to fishes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.