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Environmental fate & pathways

Biodegradation in water: screening tests

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Endpoint:
biodegradation in water: ready biodegradability
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
Propan-2-ol (Isopropyl alcohol) is both reagents used in the manufacture of IPETC/O-isopropyl ethylthiocarbamate . Therefore, the Biodegradation in water of Propan-2-ol (Isopropyl alcohol) need to be considered in the assessment of IPETC/O-isopropyl ethylthiocarbamate .
Qualifier:
equivalent or similar to guideline
Guideline:
EU Method C.5 (Degradation: Biochemical Oxygen Demand)
Deviations:
yes
Remarks:
No reference substance was reported, and results were only based on one measurement not three.
Qualifier:
equivalent or similar to guideline
Guideline:
EU Method C.6 (Degradation: Chemical Oxygen Demand)
Deviations:
not specified
Remarks:
no details were provided
GLP compliance:
no
Oxygen conditions:
aerobic
Inoculum or test system:
sewage, domestic (adaptation not specified)
Details on inoculum:
The BOD tests were conducted with partly adapted effluent from a biological sanitary waste treatment plant.

The 500 ml test solutions were seeded with a filtered 10 ml volume of the effluent from a biological sanitary waste treatment plant. In some cases an adapted seed was prepared and used.
Duration of test (contact time):
5 d
Parameter followed for biodegradation estimation:
O2 consumption
Reference substance:
not specified
Parameter:
% degradation (O2 consumption)
Value:
53
Sampling time:
5 d
Details on results:
A 5-day aerobic test with isopropyl alcohol/ propan-2-ol reported 53 % biooxidation.
Parameter:
BOD5
Value:
1.19 other: g O2/g test mat. (non-adapted)
Parameter:
BOD5
Value:
1.72 other: g O2/g test mat. (adapted)
Parameter:
COD
Value:
2.23 g O2/g test mat.
Parameter:
BOD5
Value:
53 other: % (non-adapted BOD)
Parameter:
BOD5
Value:
77 other: % (adapted BOD)
Validity criteria fulfilled:
yes
Interpretation of results:
readily biodegradable
Conclusions:
A BOD5/COD ratio ≥ 0.5 is considered as indicative of rapid degradation. Thus, a substance which passes this screening test is considered likely to biodegrade 'rapidly' in the aquatic environment, and is thus unlikely to be persistent.
Propan-2-ol (Isopropyl alcohol) is both reagents used in the manufacture of IPETC/O-isopropyl ethylthiocarbamate l. Therefore, the Biodegradation in water of Propan-2-ol (Isopropyl alcohol) need to be considered in the assessment of IPETC/O-isopropyl ethylthiocarbamate .
These results suggest that IPETC/O-isopropyl ethylthiocarbamate will be readily biodegradable and it is not expected to persist in the environment.

Executive summary:

A BOD5/COD ratio ≥ 0.5 is considered as indicative of rapid degradation. Thus, a substance which passes this screening test is considered likely to biodegrade 'rapidly' in the aquatic environment, and is thus unlikely to be persistent.

Propan-2-ol (Isopropyl alcohol) is both reagents used in the manufacture of IPETC/O-isopropyl ethylthiocarbamate . Therefore, the Biodegradation in water of Propan-2-ol (Isopropyl alcohol) need to be considered in the assessment of IPETC/O-isopropyl ethylthiocarbamate.

These results suggest that IPETC/O-isopropyl ethylthiocarbamate will be readily biodegradable and it is not expected to persist in the environment.

Endpoint:
biodegradation in water: ready biodegradability
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Justification for type of information:
Butan-1-ol (Butyl alcohol) is both reagents used in the manufacture of IPETC/ O-isopropyl ethylthiocarbamate . Therefore, the Biodegradation in water of Butan-1-ol (Butyl alcohol) need to be considered in the assessment of IPETC/O-isopropyl ethylthiocarbamate .
Qualifier:
according to guideline
Guideline:
other: BOD (Standard Methods for the Examination of Water and Wastewater. 1971. 13th Ed. American Public Health Association, New York, NY)
Principles of method if other than guideline:
BOD (Standard Methods for the Examination of Water and Wastewater. 1971. 13th Ed. American Public Health Association, New York, NY)
GLP compliance:
no
Oxygen conditions:
aerobic
Inoculum or test system:
sewage, domestic, non-adapted
Details on inoculum:
The BOD tests were conducted with partly adapted effluent from a biological sanitary waste treatment plant.

Duration of test (contact time):
20 d
Initial conc.:
3 mg/L
Based on:
test mat.
Parameter followed for biodegradation estimation:
O2 consumption
Reference substance:
not specified
Parameter:
% degradation (O2 consumption)
Value:
68
Sampling time:
5 d
Parameter:
% degradation (O2 consumption)
Value:
87
Sampling time:
10 d
Parameter:
% degradation (O2 consumption)
Value:
92
Sampling time:
15 d
Details on results:
The ready biodegradability of n-butanol was examined. After 5 days, approximately 68% of the test material was degraded. After 10 and 15 days, approximately 87 and 92% of the test material was degraded.
Validity criteria fulfilled:
yes
Interpretation of results:
readily biodegradable
Conclusions:
The ready biodegradability of n-butanol was examined. After 5 days, approximately 68% of the test material was degraded. After 10 and 15 days, approximately 87 and 92% of the test material was degraded.
Butan-1-ol (Butyl alcohol) is both reagents used in the manufacture of IPETC/O-isopropyl ethylthiocarbamate . Therefore, the Biodegradation in water of Butan-1-ol (Butyl alcohol) need to be considered in the assessment of IPETC/O-isopropyl ethylthiocarbamate .
These results suggest that IPETC/ O-isopropyl ethylthiocarbamate will be readily biodegradable and it is not expected to persist in the environment.

Executive summary:

The ready biodegradability of n-butanol was examined. After 5 days, approximately 68% of the test material was degraded. After 10 and 15 days, approximately 87 and 92% of the test material was degraded.

Butan-1-ol (Butyl alcohol) is both reagents used in the manufacture of IPETC/O-isopropyl ethylthiocarbamate. Therefore, the Biodegradation in water of Butan-1-ol (Butyl alcohol) need to be considered in the assessment of IPETC/O-isopropyl ethylthiocarbamate .

These results suggest that IPETC/O-isopropyl ethylthiocarbamate will be readily biodegradable and it is not expected to persist in the environment.

Endpoint:
biodegradation in water: ready biodegradability
Data waiving:
other justification
Justification for data waiving:
other:

Description of key information

According to “ANNEX IX- STANDARD INFORMATION REQUIREMENTS FOR SUBSTANCES MANUFACTURED OR IMPORTED IN QUANTITIES OF 100 TONNES OR MORE”, a simulation testing on ultimate degradation in surface water, the study does not need to be performed if the substance is ready biodegradable.
Propan-2-ol (Isopropyl alcohol) and Butan-1-ol (Butyl alcohol) are both reagents used in the manufacture of IPETC/O-isopropyl ethyl thiocarbamate.Therefore, the Biodegradation in water of Propan-2-ol (Isopropyl alcohol)and Butan-1-ol (Butyl alcohol) need to be considered in the assessment of IPETC/O-isopropyl ethyl thiocarbamate.
The results suggest that Propan-2-ol (Isopropyl alcohol) and Butan-1 -ol (Butyl alcohol) are readily biodegradable and therefore IPETC/O-isopropyl ethylthiocarbamate  will be readily biodegradable and it is not expected to persist in the environment.
As IPETC/O-isopropyl ethylthiocarbamate is ready biodegradable a ready biodegradability study does not need to be conducted.
Therefore testing for Biodegradation in water screening tests does not need to be performed.

Key value for chemical safety assessment

Biodegradation in water:
readily biodegradable

Additional information

According to “ANNEX IX- STANDARD INFORMATION REQUIREMENTS FOR SUBSTANCES MANUFACTURED OR IMPORTED IN QUANTITIES OF 100 TONNES OR MORE”, a simulation testing on ultimate degradation in surface water, the study does not need to be performed if the substance is ready biodegradable.

Propan-2-ol (Isopropyl alcohol) and Butan-1-ol (Butyl alcohol) are both reagents used in the manufacture of IPETC/O-isopropyl ethyl thiocarbamate .Therefore, the Biodegradation in water of Propan-2-ol (Isopropyl alcohol)and Butan-1-ol (Butyl alcohol) need to be considered in the assessment of IPETC/ O-isopropyl ethyl thiocarbamate.

The results suggest that Propan-2-ol (Isopropyl alcohol) and Butan-1-ol (Butyl alcohol) are readily biodegradable and therefore IPETC/O-isopropyl ethylthiocarbamate will be readily biodegradable and it is not expected to persist in the environment.

As IPETC/O-isopropyl ethylthiocarbamate is ready biodegradable a ready biodegradability study does not need to be conducted.

Therefore testing for Biodegradation in water screening tests does not need to be performed.