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Diss Factsheets
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EC number: 205-517-7 | CAS number: 141-98-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to terrestrial arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to terrestrial arthropods: long-term
- Data waiving:
- other justification
- Justification for data waiving:
- other:
- Endpoint:
- toxicity to terrestrial arthropods: short-term
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Justification for type of information:
- .Propan-2-ol (Isopropyl alcohol) is both reagents used in the manufacture of IPETC/ O-isopropyl ethylthiocarbamate . Therefore, Propan-2-ol (Isopropyl alcohol) need to be considered in the assessment of IPETC/O-isopropyl ethylthiocarbamate .
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Larvae were grown at low larval density on an axenic, killed yeast medium. After emergence, adults were kept on nutrient medium for three days. After three days feeding, each group of flies is transferred into an air-tight plastic vial containing 2 mL of a 3% sucrose solution supplemented with the tested concentration of alcohol. Toxicity data are expressed as the lethal concentration which kills 50% of the flies after 1, 2 or 3 days of treatment.
- GLP compliance:
- no
- Application method:
- other: % sucrose solution supplemented with the tested concentration in an airtight plastic vial
- Analytical monitoring:
- not specified
- Vehicle:
- no
- Test organisms (species):
- Drosophila melanogaster
- Animal group:
- Diptera (fruit fly (small))
- Details on test organisms:
- Experiments were carried out on two strains of French origin: a melanogaster strain from Colmar and a simulans strain from Marseille.
- Study type:
- laboratory study
- Limit test:
- no
- Total exposure duration:
- 3 d
- Test temperature:
- 25ºC
- pH (if soil or dung study):
- not applicable
- Humidity:
- not reported
- Photoperiod and lighting:
- not reported
- Details on test conditions:
- Larvae were grown at low larval density on an axenic, killed yeast medium. after emergence, adults were separated in groups of 10 females and 10 males and kept on nutrient medium for three days. After three days feeding, each group of flies is transferred into an air-tight plastic vial containing 2 mL of a 3% sucrose solution supplemented with the tested concentration of alcohol. For each test, 7 concentrations (in a geometric progression of ratio 1.25) are used and, for each concentration, 40 females and 40 males. Toxicity data are expressed as the lethal concentration which kills 50% of the flies (LC50) after 1, 2 or 3 days of treatment.
- Nominal and measured concentrations:
- not reported
- Reference substance (positive control):
- not specified
- Duration:
- 1 d
- Dose descriptor:
- LC50
- Effect conc.:
- 3.2 other: % in diet
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: males
- Duration:
- 1 d
- Dose descriptor:
- LC50
- Effect conc.:
- 25.1 other: g/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: males
- Duration:
- 1 d
- Dose descriptor:
- LC50
- Effect conc.:
- 3.4 other: % in diet
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: female
- Duration:
- 1 d
- Dose descriptor:
- LC50
- Effect conc.:
- 26.7 other: g/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: female
- Duration:
- 2 d
- Dose descriptor:
- LC50
- Effect conc.:
- 1.5 other: % in diet
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: males
- Duration:
- 2 d
- Dose descriptor:
- LC50
- Effect conc.:
- 11.8 other: g/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: males
- Duration:
- 2 d
- Dose descriptor:
- LC50
- Effect conc.:
- 1.7 other: % in diet
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: females
- Duration:
- 2 d
- Dose descriptor:
- LC50
- Effect conc.:
- 13.4 other: g/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: females
- Details on results:
- Assuming the % in diet is a volume/volume percentrage, and with a specific gravity of 0.7855 g/cm3, the LC50 correspond to:
The 1-day LC50 in males is 25.1 g/L in diet
The 1-day LC50 in females is 26.7 g/L in diet
The 2-day LC50 in males is 11.8 g/L in diet
The 2-day LC50 in females is 13.4 g/L in diet - Validity criteria fulfilled:
- not applicable
- Remarks:
- non-guideline study
- Conclusions:
- Propan-2-ol (Isopropyl alcohol) is both reagents used in the manufacture of IPETC/O-isopropyl ethylthiocarbamate . Therefore, Propan-2-ol (Isopropyl alcohol) need to be considered in the assessment of IPETC/O-isopropyl ethylthiocarbamate.
Assuming the % in diet is a volume/volume percentrage, and with a specific gravity of 0.7855 g/cm3, the LC50 correspond to:
The 1-day LC50 in males is 25.1 g/L in diet
The 1-day LC50 in females is 26.7 g/L in diet
The 2-day LC50 in males is 11.8 g/L in diet
The 2-day LC50 in females is 13.4 g/L in diet
Referenceopen allclose all
Description of key information
Propan-2-ol (Isopropyl alcohol) is both reagents used in the manufacture of IPETC/O-isopropyl ethylthiocarbamate. Therefore, Propan-2 -ol (Isopropyl alcohol) need to be considered in the assessment of IPETC/O-isopropyl ethylthiocarbamate.
Assuming the % in diet is a volume/volume percentrage, and with a specific gravity of 0.7855 g/cm3, the LC50 correspond to:
The 1-day LC50 in males is 25.1 g/L in diet
The 1-day LC50 in females is 26.7 g/L in diet
The 2-day LC50 in males is 11.8 g/L in diet
The 2-day LC50 in females is 13.4 g/L in diet
Key value for chemical safety assessment
- Short-term EC50 or LC50 for soil dwelling arthropods:
- 11 800 mg/kg soil dw
- Long-term EC10, LC10 or NOEC for soil dwelling arthropods:
- 2 360 mg/kg soil dw
Additional information
Propan-2-ol (Isopropyl alcohol) is both reagents used in the manufacture of Reaction mass of O-isopropyl ethylthiocarbamate and n-butanol and propan-2-ol. Therefore, Propan-2-ol (Isopropyl alcohol) need to be considered in the assessment of Reaction mass of O-isopropyl ethylthiocarbamate and n-butanol and propan-2-ol .
Assuming the % in diet is a volume/volume percentrage, and with a specific gravity of 0.7855 g/cm3, the LC50 correspond to:
The 1-day LC50 in males is 25.1 g/L in diet
The 1-day LC50 in females is 26.7 g/L in diet
The 2-day LC50 in males is 11.8 g/L in diet
The 2-day LC50 in females is 13.4 g/L in diet
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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