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EC number: 210-890-4 | CAS number: 625-36-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-chloropropionyl chloride
- EC Number:
- 210-890-4
- EC Name:
- 3-chloropropionyl chloride
- Cas Number:
- 625-36-5
- Molecular formula:
- C3H4Cl2O
- IUPAC Name:
- 3-chloropropanoyl chloride
- Details on test material:
- - Name of test material (as cited in study report): 3-Chlorpropionsaeurechlorid
- Physical state: liquid, clear, brown
- Storage condition of test material: room temperature, tightly closed bottle
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 3-Chlorpropionsaeurechlorid
- Physical state: liquid, clear, brown
- Storage condition of test material: room temperature, tightly closed bottle
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: Separately for each concentration 0.2151, 0.4641, 1.01, 2.15, 4.64 and 4.64 (pH-adjustment) g the test substance were added to the test water using an ultra-turrax stirrer. From the beginning of preparing the test solutions until termination of placing the fish into the aquaria 35 minutes were needed.
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Zebra fish
- Source: Charles River Aquatics, Someren, Netherlands
- Age at study initiation: ca. 4 months
- Length at study initiation (mean, range): 2.68 (2.4 - 3.0) cm
- Weight at study initiation (mean, range): 0.232 (0.16 - 0.36) g
- Feeding during test: 1 day before and during exposure
HOUSING
- The fish were kept in a flow-through tank in tap water, not chlorinated, passed through a charcoal filter and aerated with oil-free air.
- Duration of housing: About 2 months
- Mortality during the last 14 days: 0.19%
- Diet: "TETRA MIN" standard feed for aquarium fish TETRA - WERKE, MELLE, Germany, ad libitum; and on workdays generally additionally live artemia
- Adaptation: Test conditions corresponded to housing conditions
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- ca. 2.5 mmol/L
- Test temperature:
- 22 °C
- pH:
- Test concentrations without pH-adjustment (0 - 464 mg/L): 3.9 - 8.5
Test concentration with pH-adjustment (464 mg/L): 7.7 - Dissolved oxygen:
- 6.6 - 8.6 mg/L
- Nominal and measured concentrations:
- - Without pH-adjustment:
- Nominal concentration: control, 21.5, 46.4, 100, 215, 464 mg/L
- Recovery rates after 1 hour (%): < 10, 102.3, 97.0, 102.0, 103.3, 97.8
- Recovery rates after 96 hours (%): < 10, 93.0, 97.0, 99.0, 94.9, 101.5
- With pH-adjustment:
- Nominal concentration: 464 mg/L
- Recovery rates after 1 hour (%): 100.0
- Recovery rates after 96 hours (%): 95.7 - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type: Aquaria
- Material, size, fill volume: glass, 30x22x24 cm, 10 L
- Aeration: slight
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Biomass loading rate: 0.2 g/L
- Intervals of water quality measurement: 1, 24, 48, 72, 96 h
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Municipal water of the city of Frankenthal, not chlorinated and passed through a charcoal filter, aerated
- Ca/Mg ratio: 9:1
- Culture medium different from test medium: no
OTHER TEST CONDITIONS
- Adjustment of pH: yes, the pH of the highest concentration (464 mg/L) was adjusted
- Photoperiod: 16 h light, 8 h darkness
EFFECT PARAMETERS MEASURED: mortality and symptoms after 1, 4, 24, 48, 72, 96 h
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 2.15
- Range finding study: yes (LC50 after 96 h: > 100 mg/L)
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 - < 215 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- analytically verified
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 99 - < 204 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Behavioural abnormalities: apathy, narcotic-like state
- Mortality of control: none - Reported statistics and error estimates:
- Finney, D.J., Probit Analysis, Cambr. Univ. Press, 3rd ed., 1971; certain aspects of this method have been modified.
Any other information on results incl. tables
- Sublethal observations / clinical signs:
Cumulative mortalities:
Concentration (mg/L)
No. of fish at test start
Dead fish after
1 h
4 h
24 h
48 h
72 h
96 h
0 (control)
10
0
0
0
0
0
0
21.5
10
0
0
0
0
0
0
46.4
10
0
0
0
0
0
0
100
10
0
0
0
0
0
0
215
10
0
0
5
8
8
8
464
10
10
10
10
10
10
10
464*
10
0
10
10
10
10
10
* pH-adjusted
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.