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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-GLP, non guideline study, available as unpublished report, restrictions in design and/or reporting but otherwise adequate for assessment.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1968
Report date:
1968
Reference Type:
other: TSCAT
Title:
TSCAT
Author:
US EPA
Year:
1992
Bibliographic source:
TSCATS: 8ECP, Doc. I.D: 88-920003052, 27.5.92; submitting organisation: BASF AG

Materials and methods

Principles of method if other than guideline:
The test substance was applied to white Vienna rabbits for 1 min, 5 min, 15 min and 20 h under occlusive conditions. The skin was left intact. Animals were observed for 8 days and skin changes were observed on working days. Findings were recorded after 24 hours and at the end of the observation period. Findings were graded as described in OECD test guideline 404.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-chloropropionyl chloride
EC Number:
210-890-4
EC Name:
3-chloropropionyl chloride
Cas Number:
625-36-5
Molecular formula:
C3H4Cl2O
IUPAC Name:
3-chloropropanoyl chloride
Details on test material:
- Name of test material (as cited in study report): beta-Chlorpropionylchlorid
- Analytical purity: ca. 97 %

Test animals

Species:
rabbit
Strain:
Vienna White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 2.47 and 2.8 kg

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
other: untreated skin of the same animals
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): ca. 0.5 mL
Duration of treatment / exposure:
1, 5, 15 minutes and 20 hours
Observation period:
8 days
Number of animals:
2
Details on study design:
TEST SITE
- % coverage: 2.5 x 2.5 cm

REMOVAL OF TEST SUBSTANCE
- Washing: Lutrol:water (1:1)

SCORING SYSTEM: equivalent to the scoring system described in OECD 404

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
other: 24 hour
Score:
3
Max. score:
4
Reversibility:
fully reversible within: 8 days
Remarks on result:
other: 1 minute exposure
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
other: 24 hour
Score:
2
Max. score:
4
Remarks on result:
other: 1 minute exposure. Slight scaling at day 8
Irritation parameter:
edema score
Basis:
animal: #1 and #2
Time point:
other: 24 hour
Score:
0
Max. score:
4
Remarks on result:
other: 1 minute exposure
Irritation parameter:
erythema score
Basis:
animal: #1 and #2
Time point:
other: 24 hour
Score:
2
Max. score:
4
Reversibility:
not fully reversible within: 8 days.
Remarks on result:
other: 5 minutes exposure. Effect observed arround test-patch. Necrosis was observed within 24 hour.
Irritation parameter:
edema score
Basis:
animal #1
Time point:
other: 24 hour
Score:
3
Max. score:
4
Reversibility:
fully reversible within: 8 days
Remarks on result:
other: 5 minutes exposure
Irritation parameter:
edema score
Basis:
animal #2
Time point:
other: 24 hour
Score:
0
Max. score:
4
Remarks on result:
other: 5 minute exposure
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
other: 24 hour
Score:
2
Max. score:
4
Reversibility:
not fully reversible within: 8 days
Remarks on result:
other: 15 minutes exposure. Effect observed arround test-patch. Necrosis was observed within 24 hour.
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
other: 24 hour
Score:
0
Max. score:
4
Remarks on result:
other: 15 minutes exposure. Necrosis was observed within 24 hour.
Irritation parameter:
edema score
Basis:
animal #1
Time point:
other: 24 hour
Score:
3
Max. score:
4
Reversibility:
fully reversible within: 8 days
Remarks on result:
other: 15 minutes exposure
Irritation parameter:
edema score
Basis:
animal #2
Time point:
other: 24 hour
Score:
0
Max. score:
4
Remarks on result:
other: 15 minutes exposure
Irritation parameter:
erythema score
Basis:
animal: #1 and #2
Time point:
other: 24 hour
Score:
2
Max. score:
4
Reversibility:
fully reversible within: 8 days
Remarks on result:
other: 20 hour exposure. Effect observed arround test-patch. Necrosis was observed within 24 hour.
Irritation parameter:
edema score
Basis:
animal: #1 and #2
Time point:
other: 24 hour
Score:
3
Max. score:
4
Reversibility:
fully reversible within: 8 days
Remarks on result:
other: 20 hour exposure
Irritant / corrosive response data:
Full thickness necrosis of the skin was observed after exposure for 5 and 15 minutes as well as after 20 hours at the end of the observation period.
Necrosis was already observed at the 24 h reading (5 and 15 minutes, 20 hours).

Applicant's summary and conclusion