Registration Dossier
Registration Dossier
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EC number: 810-432-9 | CAS number: 1487263-87-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2,3-bis(acetyloxy)propyl 8-(3-octyloxiran-2-yl)octanoate
- Cas Number:
- 1487263-87-5
- Molecular formula:
- C25H44O7
- IUPAC Name:
- 2,3-bis(acetyloxy)propyl 8-(3-octyloxiran-2-yl)octanoate
- Test material form:
- other: oily liquid
Constituent 1
Test animals / tissue source
- Species:
- other: bovine
- Strain:
- other: corneas
Test system
- Controls:
- yes
Results and discussion
Any other information on results incl. tables
The eye irritancy potential of Glycery 1,2-diacetate-3-(9,10-)epoxyoctadecanate was investigated in the bovine corneal opacity and permeability assay. The test item was tested as provided by the sponsor. The following meanin vitroirritation score was calculated: 0.27 Therefore the test item was classified into UN GHS No Category. Thein vitroirritation score obtained with the positive control fell within the two standard deviations of the current historical mean and therefore this assay is considered to be valid. The negative control responses resulted in opacity and permeability values that are less than the established upper limits for background bovine corneas treated with the respective negative control. |
For detailed data seeTable 2toTable 5in the appendix.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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