Registration Dossier
Registration Dossier
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EC number: 810-432-9 | CAS number: 1487263-87-5
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- yes (incl. QA statement)
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 2,3-bis(acetyloxy)propyl 8-(3-octyloxiran-2-yl)octanoate
- Cas Number:
- 1487263-87-5
- Molecular formula:
- C25H44O7
- IUPAC Name:
- 2,3-bis(acetyloxy)propyl 8-(3-octyloxiran-2-yl)octanoate
- Test material form:
- other: oliy liquid
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and TA 102
- Metabolic activation:
- with and without
Controls
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- not specified
- Positive controls:
- yes
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and TA 102
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not valid
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
On the basis of the results interpreted according to OECD 471:1997, the test substance “GLYCERY 1,2- DIACETATE-3-(9,10-) EPOXYOCTADECANATE” tested as recommended by Standards, proved to be NOT MUTAGENIC for all the test strains, either in the presence or absence of metabolic activation.
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