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EC number: 268-610-1 | CAS number: 68131-13-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986-09-04 to 1986-10-09
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically well performed study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Naphthenic acids, reaction products with diethylenetriamine
- EC Number:
- 268-610-1
- EC Name:
- Naphthenic acids, reaction products with diethylenetriamine
- Cas Number:
- 68131-13-5
- Molecular formula:
- not applicable
- IUPAC Name:
- Naphthenic acids, reaction products with diethylenetriamine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Sesame oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20% in 2000 mg/kg Group; 5% in 500 mg/kg Group
- Amount of vehicle (if gavage): 10 ml /kg body weight - Doses:
- 2000 mg/kg (male); 500, 2000 mg/kg (female)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Daily during the study
- Necropsy of survivors performed: yes
- Other examinations performed:
clinical signs During the first 10, 30, 60 minutes, 2, 4 and 6 hours after the administration. Twice daily during days 1-14
body weight: On test day 0, 7 and 14 (after the administration)
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- On test day 8, one female animal was found dead in 2000 mg/kg group (20% mortality)
- Clinical signs:
- other: One female that was found dead on day 8 exhibited clinical signs on day 6 and 7. No clinical sign was found in other animals during the study.
- Gross pathology:
- The animal died on day 8 was found to have light pink colored lung.
Any other information on results incl. tables
Table: Body weight development |
|||
Sex/dose level |
Initial body weight
|
Body weight gain: day 0-7 |
Body weight gain: day 7-14 |
Males/2000 mg/kg bw |
176 |
55 |
40 |
180 |
47 |
44 |
|
175 |
50 |
48 |
|
178 |
63 |
52 |
|
186 |
52 |
47 |
|
179 ± 4 (n=5) |
53 ± 6 (n=5) |
46 ± 4 (n=5) |
|
Females/2000 mg/kg bw |
175 |
16 |
9 |
172 |
28 |
22 |
|
180 |
18 |
7 |
|
180 |
17 |
15 |
|
178 |
-11 |
* |
|
177 ± 3 (n=5) |
14 ± 15 (n=5) |
13 ± 7 (n=4) |
|
Females/500 mg/kg bw |
171 |
34 |
11 |
|
173 |
26 |
11 |
|
170 |
27 |
7 |
|
179 |
31 |
15 |
|
173 |
37 |
8 |
|
173 ± 3 (n=5) |
31 ± 5 (n=5) |
10 ± 3 (n=5) |
*Found dead |
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- The median lethal dose of Dodigen 1481 after single oral administration to rats, observed over a period of 14 days is:
LD50 (Rat): greater than 2000 mg/kg body weight - Executive summary:
NA-DETA was given to rats per gavage at dose levels of 2000 mg/kg bw for males and 2000 and 500 mg/kg bw for females.
At 2000 mg/kg bw, one female out of five died 7 days after treatment and exhibited body weight reduction prior to death. The survived animals exhibted transiently reduced body weight gain.
No effect was found for males upon application of 2000 mg/kg bw and for females upon application of 500 mg/kg bw.No classification is warranted for the acute oral toxicity of NA-DETA
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