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Diss Factsheets
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EC number: 231-106-7 | CAS number: 7439-97-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
- NTP study rats (1993)
- NTP study mice (1993)
- human data (Barregård_1990 and Cragle_1984), see section 7.10.2
Key value for chemical safety assessment
Justification for classification or non-classification
Additional information
There was some evidence of a carcinogenic activity in male rats based on the increased incidence squamous cell papillomas of the forestomach. Marginally increased incidence of thyroid follicular adenomas and carcinomas may have been related to mercuric chloride. There was equivocal evidence of a carcinogenic activity in female rats based on two squamous cell papillomas of the forestomach.
There was equivocal evidence of a carcinogenic activity in male mice based on the occurance of two renal tubule adenomas and one renal tubule adenocarcinomas, and there was no evidence of a carcinogenic activity in female mice. The primary toxic changes occurred in kidneys.
In conclusion, the evidence for a mutagenic or carcinogenic potential of Hg in both animal (oral exposure) and epidemiological studies (occupational inhalation exposure) is equivocal, and it is so far lacking in humans at low exposure concentrations < 50 µg/g creatinine in urine. The mutagenic or carcinogenic potential of Hg seems to be related to metal induced oxidative stress and thus, if a potential is present in humans, a threshold effects is hypothetically possible.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.