Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 432-400-1 | CAS number: 10102-09-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Platinum dinitrate failed to induce skin sensitisation in a GMPT study, conducted according to OECD Test Guideline 406 and to GLP, in which a group of ten guinea pigs were dermally challenged with 1 or 0.5% of the test compound following a two stage induction with 1% by intradermal injection and 5% applied topically (Sanders, 1999).
No respiratory tract sensitisation data are available.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Study performed: 26-Jul-1999 to 28-Aug-1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study (OECD), to GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.6 (Skin Sensitisation)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- Study conducted in 1999
- Species:
- guinea pig
- Strain:
- Dunkin-Hartley
- Sex:
- male/female
- Details on test animals and environmental conditions:
TEST ANIMALS
- Source: David Hall Limited, Burton-on-Trent, Staffordshire, UK
- Age at study initiation: ~8-12 weeks
- Weight at study initiation: 318-382 g
- Housing: singly or in pairs in solid-floor polypropylene cages furnished with woodflakes
- Diet: free access to food (Guinea Pig FD1 Diet, Special Diets Services Limited, Witham, Essex, UK) was allowed throughout the study.
- Water: free access to mains tap water was allowed throughout the study.
- Acclimation period: >=5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17-23
- Humidity (%): 30-70
- Air changes (per hr): ~15
- Photoperiod (hrs dark / hrs light): 12/12- Route:
- intradermal and epicutaneous
- Vehicle:
- arachis oil
- Concentration / amount:
- Intradermal induction: 1%
Topical induction: 5%
Topical challenge: 1% and 0.5% (“the highest non-irritant concentration…and one lower concentration”, one on each flank of each test animal) - Route:
- epicutaneous, occlusive
- Vehicle:
- arachis oil
- Concentration / amount:
- Intradermal induction: 1%
Topical induction: 5%
Topical challenge: 1% and 0.5% (“the highest non-irritant concentration…and one lower concentration”, one on each flank of each test animal) - No. of animals per dose:
- Main study: 10 test and 5 control
- Details on study design:
RANGE FINDING TESTS: performed to select concentrations for main study
- Positive control substance(s):
- yes
- Remarks:
- 2-Mercaptobenzothiazole at 5% in arachis oil
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 0.5 and 1%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- Bodyweight gains of guinea pigs in the test group, between Day 0 and Day 24, were comparable to those observed in the control group animals over the same period.
- Remarks on result:
- other: see Remark
- Remarks:
- Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 0.5 and 1%. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: Bodyweight gains of guinea pigs in the test group, between Day 0 and Day 24, were comparable to those observed in the control group animals over the same period..
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 0%
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Clinical observations:
- Bodyweight gains of guinea pigs in the test group, between Day 0 and Day 24, were comparable to those observed in the control group animals over the same period.
- Remarks on result:
- other: see Remark
- Remarks:
- Reading: 1st reading. . Hours after challenge: 24.0. Group: negative control. No with. + reactions: 0.0. Total no. in groups: 5.0. Clinical observations: Bodyweight gains of guinea pigs in the test group, between Day 0 and Day 24, were comparable to those observed in the control group animals over the same period..
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 0.5 and 1%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- Bodyweight gains of guinea pigs in the test group, between Day 0 and Day 24, were comparable to those observed in the control group animals over the same period.
- Remarks on result:
- other: see Remark
- Remarks:
- Reading: 2nd reading. . Hours after challenge: 48.0. Group: test group. Dose level: 0.5 and 1%. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: Bodyweight gains of guinea pigs in the test group, between Day 0 and Day 24, were comparable to those observed in the control group animals over the same period..
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 0%
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Clinical observations:
- Bodyweight gains of guinea pigs in the test group, between Day 0 and Day 24, were comparable to those observed in the control group animals over the same period.
- Remarks on result:
- other: see Remark
- Remarks:
- Reading: 2nd reading. . Hours after challenge: 48.0. Group: negative control. No with. + reactions: 0.0. Total no. in groups: 5.0. Clinical observations: Bodyweight gains of guinea pigs in the test group, between Day 0 and Day 24, were comparable to those observed in the control group animals over the same period..
- Reading:
- other: Positive Control
- Hours after challenge:
- 0
- Group:
- positive control
- Dose level:
- 0%
- No. with + reactions:
- 0
- Total no. in group:
- 0
- Clinical observations:
- Historical positive control data for the CRO was supplied in the test report and was seen to be valid
- Remarks on result:
- not measured/tested
- Remarks:
- Historical positive control data for the CRO was supplied in the test report and was seen to be valid
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- Platinum dinitrate failed to induce skin sensitisation in an OECD Test Guideline 406 GPMT, to GLP, in which a group of ten guinea pigs were dermally challenged with 0.5 or 1% of the test compound following a two stage induction with 1% by intradermal injection and 5% applied topically.
- Executive summary:
The ability of platinum dinitrate to induce contact sensitisation was assessed in a guinea pig maximisation test (GPMT), conducted according to OECD Test Guideline 406 and to GLP, using groups of 10 test and 5 control animals.
Guinea pigs were induced with 1% by intradermal injection, followed one week later by a second induction by topical application of 5% of the test substance under a 48-hr occlusive patch. Control animals were similarly treated but without the test substance. Challenge doses of 0.5 or 1% were applied under an occlusive patch for 24 hr, three weeks after the start of induction, to both test and control animals. These doses were selected after a preliminary range-finding study to determine irritation. Scoring of the treated areas was carried out 24 and 48 hr after removal of the patches.
No positive reactions were observed in the test or control animals on examination at 24 and 48 hr after removal of the challenge patches. Platinum dinitrate was not a contact sensitiser in this GPMT.
Based on the results of this study, no classification for skin sensitisation is required according to EU CLP criteria (EC 1272/2008).
Reference
No skin reactions were noted at the challenge sites of the test or control group animals at the 24 or 48-hour observations.
No results tables attached, since all scores were 0.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
No relevant human sensitisation data were identified.
The ability of platinum dinitrate to induce contact sensitisation was assessed in an OECD Test Guideline 406 guinea pig maximisation test (GPMT), conducted to GLP, using groups of 10 test and 5 control animals. Guinea pigs were induced with 1% by intradermal injection, followed one week later by a second induction by topical application of 5% of the test substance under a 48-hr occlusive patch. Control animals were similarly treated but without the test substance. Challenge doses of 0.5 or 1% were applied under an occlusive patch for 24 hr, three weeks after the start of induction, to both test and control animals. These doses were selected after a preliminary range-finding study to determine irritation. Scoring of the treated areas was carried out 24 and 48 hr after removal of the patches. No positive reactions were observed in the test or control animals on examination at 24 and 48 hr after removal of the challenge patches. Overall, platinum dinitrate was not a contact sensitiser in a reliable GPMT (Sanders, 1999), and thus would not require classification as a skin sensitiser according to EU CLP criteria (EC 1272/2008).
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
No respiratory tract sensitisation data are available. A new study was not conducted as no standard and validated test method is available and it is not a REACH Standard Information Requirement.
Justification for classification or non-classification
Based on the lack of skin sensitisation apparent in guinea pigs, platinum dinitrate does not require classification for skin sensitisation according to EU CLP criteria (EC 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.