p-nitrophenyl dihydrogen phosphate, compound with 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:2)

Oxidising properties

Administrative data

Endpoint:

oxidising solids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

7 December 2020

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2020

Report date:

2021

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

UN Manual of Tests and Criteria: Test O.1 (Test for oxidizing solids)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

impurity 1

Reference substance name:

Methanol

EC Number:

200-659-6

EC Name:

Methanol

Cas Number:

67-56-1

Molecular formula:

CH4O

IUPAC Name:

methanol

impurity 2

Reference substance name:

Acetone

EC Number:

200-662-2

EC Name:

Acetone

Cas Number:

67-64-1

Molecular formula:

C3H6O

IUPAC Name:

acetone

impurity 3

Reference substance name:

Water

EC Number:

231-791-2

EC Name:

Water

Cas Number:

7732-18-5

Molecular formula:

H2O

IUPAC Name:

Oxidane

Constituent 1

Reference substance name:

p-nitrophenyl dihydrogen phosphate, compound with 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:2)

EC Number:

269-198-6

EC Name:

p-nitrophenyl dihydrogen phosphate, compound with 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:2)

Cas Number:

68189-42-4

Molecular formula:

C6H6NO6P.2C4H11NO3

IUPAC Name:

4-nitrophenyl dihydrogen phosphate - 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:2)

Test material form:

solid

Details on test material:

Batch / Lot No. 46587100

Specific details on test material used for the study:

Batch No.: 46587100
Storage: Refrigerator (approx. 2-8°C)

Study design

Contact with:

powdered cellulose

Duration of test (contact time):

3 min

Results and discussion

Test results (Oxidising solids)

Test results (Oxidising solids) 1

Key result

Sample tested:

4:1 sample-to-cellulose ratio

Parameter:

mean burning time

Result:

> 180 s

Test results (Oxidising solids) 2

Key result

Sample tested:

1:1 sample-to-cellulose ratio

Parameter:

mean burning time

Result:

> 180 s

Test results (Oxidising solids) 3

Key result

Sample tested:

reference: 3:7 mixture potassium bromate + cellulose

Parameter:

mean burning time

Result:

120 s

Any other information on results incl. tables

Residual moisture

Since the test item is stored in the refrigerator, it was not dried and was tested as received. The reference item Potassium Bromate contained a residual moisture of < 0.1 wt% which was determined by drying at 65 °C. The reference item Cellulose contained a residual moisture of 6.06 wt% which was determined by drying at 105 °C.

Oxidizing properties

The results of the reference mixtures of potassium bromate and cellulose are shown in the table below:

Potassium bromate- Cellulose-ratio	Test 1 / s	Test 2 / s	Test 3 / s	Test 4 / s	Test 5 / s	Average / s
3:7	116	136	120	117	112	120

The tests of the mixtures with the potassium bromate-cellulose-ratios 2:3 and 3:2 were not performed, since the burning time of the mixtures of the test item with cellulose was higher than the burning time of the reference mixtures with the potassium bromate-cellulose-ratio 3:7.

The results of the mixtures of the test item and cellulose are shown in the table below:

Test item- Cellulose-ratio	Test 1 / s	Test 2 / s	Test 3 / s	Test 4 / s	Test 5 / s	Average / s
4:1	>180	>180	>180	>180	>180	>180
1:1	>180	>180	>180	>180	>180	>180

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The burning time of the mixtures of the test item 4-NPP, di-TRIS (CAS no. 68189-42-4) with cellulose (4:1 and 1:1) was higher than the burning time of the reference mixture of potassium bromate and cellulose (3:7). Due to the test results the test item does not have to be classified as oxidizing solid.
According to the results of the test on oxidizing properties of solids, the test item is classified as follows:
UN Transport Regulation: The test item does not have to be classified as oxidizing solid in Class 5, Division 5.1 according to the UN Transport Regulation.
GHS and Regulation (EC) No 1272/2008 (CLP Regulation), Annex I: 2.14: The test item does not have to be classified as oxidizing solid according to GHS and Regulation (EC) No 1272/2008 (CLP Regulation) Annex I: 2.14.

Executive summary:

The burning time of the mixtures of the test item 4-NPP, di-TRIS (CAS no. 68189-42-4) with cellulose (4:1 and 1:1) was higher than the burning time of the reference mixture of potassium bromate and cellulose (3:7). Due to the test results the test item does not have to be classified as oxidizing solid.
According to the results of the test on oxidizing properties of solids, the test item is classified as follows:
UN Transport Regulation: The test item does not have to be classified as oxidizing solid in Class 5, Division 5.1 according to the UN Transport Regulation.
GHS and Regulation (EC) No 1272/2008 (CLP Regulation), Annex I: 2.14: The test item does not have to be classified as oxidizing solid according to GHS and Regulation (EC) No 1272/2008 (CLP Regulation) Annex I: 2.14.