Registration Dossier
Registration Dossier
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EC number: 420-920-1 | CAS number: 128446-35-5
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Gould, S. and R. C. Scott (2005). "2-Hydroxypropyl-beta-cyclodextrin (HP-beta-CD): a toxicology review." Food Chem Toxicol 43(10): 1451-1459.
"A separate oral study in rats was also conducted by Gerloczy et al. (1990) and showed that up to 6% of a sin gle oral dose was absorbed from the gastrointestinal tract within 5 min. Of the dose administered, approximately 3% was eliminated by the kidney in the urine and 70% in the faeces within 72 h. This finding concurs with Monbaliu et al. (1990) data following oral administration. Analysis of exhaled air showed that 3% of the total dose was metabolised. Tissue distribution analysis showed that the largest amounts of HP-b-CD were detected in the liver (3–5% of the dose) and kidneys (0.2–0.35%) (Gerloczy et al., 1990), suggesting that there may be a slight difference in distribution depending
upon the route of administration; Monbaliu et al. (1990) had shown the kidney as the major organ containing HP-b-CD following intravenous administration"
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 6
Additional information
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