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EC number: 420-920-1 | CAS number: 128446-35-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Hydrolysis:
The test article, hydroxypropylated .beta.-cyclodextrin , was tested in The Abiotic Degradation by hydrolysis at three different pH values according to OECD Guideline 111.
Hydrolysis is one of the most important naturally occurring reactions in the environment and consequently represents one of the most important degradation pathways. Hydrolysis is defined as the reaction of chemicals with water resulting in the addition of water to the chemical, the substitution of OH- for a group in the chemical, or degradation of the chemical by another hydrolytic pathway. While known to be independent of factors such as sunlight, presence or absence of microbial populations and extent of oxygen supply, the rate of hydrolysis is dependent on pH, temperature and the concentration of the chemical. It has been demonstrated by Mabey and Mill (1978) that for twelve classes of organic chemicals, rates of hydrolysis obtained in the laboratory are comparable to naturally occurring rates. Therefore, hydrolysis studies provide useful information for the evaluation of the persistence of a chemical in the aquatic environment.
The objective of this study was to determine ifhydroxypropylated .beta.-cyclodextrinis stable in water at three different pH values so that the importance of hydrolysis as a transformation route can be better assessed with regard to the overall potential for persistence and/or degradation of the test substance in the environment. This study was initiated on 8 April 1997, the day the Study Director signed the protocol, and was completed on the day the StUdy Director signed the final report. The experimental phase of this study was conducted from 8 to 13 May 1997 at Springborn Laboratories, Inc. (SLJ), located in Wareham, Massachusetts. The analytical chemistry was conducted at Midwest Research Institute, Kansas City, Missouri and the data is archived there. The test system raw data and the final report produced during this study are stored in Springborn's archives at the above location.
After 5 days at 50°C +/- 1 °Chydroxypropylated .beta.-cyclodextrindegraded by 1.1%, -4.2%, and 1.9% at pH 4, 7, and 9, respectively. Since the degradation at all pHs tested was less than 10% after being exposed to optimum hydrolysis conditions (i.e., 5 days at 50 +/-0.1 °C),hydroxypropylated .beta.-cyclodextrinis considered hydrolytically stable.
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