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EC number: 406-077-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 406-077-0
- EC Name:
- -
- Molecular formula:
- Hill formula: C53H29Cl2Cu2K3N18Na4O21S5
- IUPAC Name:
- dicopper(2+) tripotassium tetrasodium 2-{[({2-[3-({4-[(3-{[4-({3-[({[2-(2-carboxylato-5-sulfonatophenyl)diazen-1-yl](phenyl)methylidene}amino)azanidyl]-2-oxido-5-sulfonatophenyl}amino)-6-chloro-1,3,5-triazin-2-yl](methyl)amino}-4-sulfonatophenyl)amino]-6-chloro-1,3,5-triazin-2-yl}amino)-2-oxido-5-sulfonatophenyl]hydrazin-2-id-1-ylidene}(phenyl)methyl)imino]amino}-4-sulfonatobenzoate
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Gaukler, Offenbach/Main, Germany
- Age at study initiation: young adult animals
- Weight at study initiation: male: 2.3 kg; females: 2.41 and 2.48 kg
- Housing: single
- Diet: Kliba 341, 4 mm; Klingentalmühle AG, Switzerland; ca. 130 g/animal/day
- Water: ca. 250 mL tap water/animal/day
- Acclimation period: at least 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 30 - 70
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 12. Feb. 1990 To: 27. Feb 1990
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.1 mL bulk volume (about 69 mg of the comminuted test substance)
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 15 d. Readings: 1h, 24h, 48h, 72h, 8d, 15d. A check for mortality was made twice each workday and once on Saturday, Sunday or public holidays.
- Number of animals or in vitro replicates:
- 3 ( 1 male and 2 females)
- Details on study design:
- The test substance was applied in a single dose to the conjunctival sac of the right eyelid. The substance was not washed out.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 d
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: #1 and #2
- Time point:
- 24/48/72 h
- Score:
- 2.33
- Max. score:
- 3
- Reversibility:
- fully reversible within: 15 d
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 3
- Reversibility:
- fully reversible within: 8 d
- Remarks on result:
- probability of weak irritation
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- Under the study conditions, the test substance caused irritation to the conjunctiva of 2 rabbits with a score >= 2. All effects were reversible within the 15 days observation period
- Executive summary:
A study was conducted to determine the eye irritation/corrosion potential of the test substance in White Vienna rabbits according to OECD Guideline 405 and EU Method B.5, in compliance with GLP.
0.1 mL of the test substance (about 69 mg) was applied in a single dose to the conjunctival sac of the right eyelid of each animal. The substance was not washed out. The untreated eye served as negative control. Readings were taken at 1, 24, 48, 72h, then 8 and 15 d. The average score (24, 48, 72 h) for irritation was calculated to be 0.0 for corneal opacity and iris. The index for chemosis was 1.33 in all three rabbits; conjunctival redness was 2.33 in 2 animals and 1.33 in one rabbit. The findings were reversible in all animals within 8 or 15, days of application. Under the study conditions, the test substance caused conjunctival reddening in 2 rabbits with a score of >=2 and has hence to be classified as irritating to eyes.
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