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EC number: 406-077-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 406-077-0
- EC Name:
- -
- Molecular formula:
- Hill formula: C53H29Cl2Cu2K3N18Na4O21S5
- IUPAC Name:
- dicopper(2+) tripotassium tetrasodium 2-{[({2-[3-({4-[(3-{[4-({3-[({[2-(2-carboxylato-5-sulfonatophenyl)diazen-1-yl](phenyl)methylidene}amino)azanidyl]-2-oxido-5-sulfonatophenyl}amino)-6-chloro-1,3,5-triazin-2-yl](methyl)amino}-4-sulfonatophenyl)amino]-6-chloro-1,3,5-triazin-2-yl}amino)-2-oxido-5-sulfonatophenyl]hydrazin-2-id-1-ylidene}(phenyl)methyl)imino]amino}-4-sulfonatobenzoate
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gaukler, Offenbach/Main, Germany
- Age at study initiation: young adult animals
- Weight at study initiation: males: 2.4 and 2.61 kg; female: 2.45 kg
- Housing: single
- Diet: Kliba 341, 4 mm; Klingentalmühle AG, Switzerland; ca. 130 g/animal/day
- Water: ca. 250 mL tap water/animal/day
- Acclimation period: at least 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 30 - 70
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 12. Feb. 1990 To: 14. Feb 1990
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- moistened with water to form a paste
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.5 g
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 72 h; Readings: 30 to 60 min after removal of the patch and 24 h, 48 h, and 72 h after the beginning of applikation
Check for mortality: every work day and once on Saturdays, Sundays and public holidays. - Number of animals:
- 3 (2 males and 1 female)
- Details on study design:
- Application
The test substance was applied in a single dose to the intact untreated skin. The test patch was secured in position with a semi occlusive dressing; the test substance was removed at the end of the exposure period with Lutrol and Lutrol/water (1:1).
Clipping of the fur: At least 24 hours before the test, the fur was removed by clipping the dorsal part of the trunk of the animals. Only animals with healthy intact skin have been used.
Application site: upper third of the back or flanks.
Negative control: Untreated skin sites of the same animal.
Application volume: The test patch (2.5 cm x 2.5 cm) was covered with dose of 0.5 g of the unchanged solid test substance and has been moistened with aqua bidest (because of the natural moisture of the skin, distilled water was used so that the test has been carried out under as physiological conditions as possible).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: #1 and #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the study conditions, the test substance was not irritating to skin.
- Executive summary:
A study was conducted to determine the skin irritation/corrosion potential of the test substance in Vienna White rabbits according to OECD Guideline 404 and EU Method B.4, in compliance with GLP.
0.5 g of the unchanged test substance was applied in a single dose to the intact untreated skin of the 3 New Zealand rabbits for 4 h. The test patch was secured in position with a semi-occlusive dressing and the test substance was removed at the end of the exposure period with Lutrol and Lutrol/water (1:1). The average score (24, 48, and 72 h) for irritation was calculated to be 0.0 in 2 and 0.3 in one rabbit for erythema and 0.0 for edema. The skin findings were reversible within 72 h, thus the study was terminated after 72 h. Under the study conditions, the test substance was not irritating to skin.
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