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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 947-999-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
An evaluation of the inherent properties of the test substance is performed against the ANNEX XIII criteria. If insufficient data were available, the screening criteria as laid down in ECHA Guidance on information requirements and chemical safety assessment Chapter R.11: PBT Assessment (2014) were applied.
The persistency assessment is based on the screening criteria in Annex XIII of the REACH Regulation. The biodegradation potential of the test substance was assessed using QSAR with the Biowin v4.10 plug-in from EPISUITE v4.1 from US EPA. The Biowin 3 result is "weeks_months" and the Biowin 5 probability is less than 0.5; therefore the prediction is not readily biodegradable. In addition, Biowin 6 also predicted to be not readily biodegradable, corresponding to a degradation in the OECD 301C test. In conclusion, it's expected that the substance is not readily biodegradable. Further, the substance displays properties that indicate persistency within the environment. Due to the extremely low water solubility (1.649e-05 mg/L, QSAR with the WSKOW v1.42 plug-in from EPISUITE v4.1 from US EPA), hydrolysis of the substance is unlikely to occur. As such, the substance fulfils the requirements of Annex XIII, Paragraph 1.1 based on evaluation of available data, and can be considered to be P and vP based in this data. It can therefore be concluded that based on the criteria mentioned above the substance is potentially P/vP.
The bioaccumulation assessment is based on the screening criteria in Annex XIII of the REACH Regulation. The bioaccumulation potential of the test substance was assessed using QSAR with the Kowwin v1.68 plug-in from EPISUITE v4.1 from US EPA. The Kowwin result is a partition coefficient (Log Kow) of 8.82. A partition coefficient in excess of 4.5 is considered to be of concern as potential for bioaccumulation, according to screening criteria for bioaccumulation in ECHA guidance (Chapter R.11 PBT Assessment). The likely reliability of the log Kow is, however, considered to diminish above a value of 6, as noted in Appendix R.11-1 Annex 1 of ECHA guidance on PBT Assessment. Substances with log Kow between 4.5 and 6 are considered likely to be highly accumulating; however no substantial bioconcentration is assumed for compounds having log K ow with values less than 4.5 or greater than 6. For compounds having log Kow greater than 6, a gradual decrease of the BCF is observed and it has been hypothesised within the published literature that a high log Kow is more an effect of solubility than a tendency of the substance to be lipophilic. This is further supported by the estimation based on EPIWIN that the log BCF was determined to be 0.6 (BCF = 3.978 L/kg wet-wt), considerably below the threshold of concern derived by the REACH criteria of 2000 (B) and 5000 (vB). The available evidence on the bioaccumulation potential for the substance indicates that the screening criteria for bioaccumulation potential (B and vB) are not met. The substance is therefore concluded not to have a bioaccumulative potential (not B / not vB).
The toxicity assessment is based on the screening criteria in Annex XIII of the REACH Regulation. No ecotoxicological and toxicological data are available on the test substance. Read-across was done with LABS Na as the source substance based on a worst-case approach. The target substance is very likely not acutely toxic to aqueous organisms, as it is expected that the obtained no effect concentration (NOEC) would be at or above the maximum concentration exposed to the organisms. The source substance for the read-across is not classified as carcinogenic (Cat. 1 or 2), as mutagenic (Cat. 1 or 2), or as reproductive toxicant (Cat. 1, 2, or 3), nor as STOT RE Cat. 1 or 2 according to the Regulation EC N° 1272/2008. The same is assumed for the target substance. As such, based on evaluation of available data, the test substance cannot be considered to be “T”. Hence, it does not fulfill the criteria to be considered as Toxic (not T).
Taking into account the conclusions that the substance is potentially P/vP, not B/vB and not T, the substance should not be considered as a PBT/vPvB substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.