Registration Dossier
Registration Dossier
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EC number: 216-388-1 | CAS number: 1571-33-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- Phosphonic Acid EC 237-066-7; CAS 13598-36-2 has been identified as a relevant surrogate substance for read-across to the target substance. Phosphonic acid has a harmonised EU classification in Annex VI of CLP: Skin Corr 1A H314; Acute Oral Toxicity 4 H302.
It is proposed that the endpoint for skin corrosion be read across from the surrogate substance, using the pH and acid dissociation constant as relevant physical properties relating to skin corrosion. According to the Registration dossier for phosphonic acid, the dissociation constants for both that acid and phenylphosphonic acid have been determined in the following publications: Dissociation constants of certain phosphorous-containing acids in aliphatic alcohols; Kreshkov A (1966) Russian Journal of Physical Chemistry vol 40 no 9. Comparison of Acid strengths of Orthophosphoric acid, thioophosphoric acid, phenylphosphonic acid, and monophenyl Phosphate in aqueous Potassium Chloride solutions Makitie and Konttinen; Acta Chem Scand 23 (1969) No 4, 1459-1461.
Cross-reference
- Reason / purpose for cross-reference:
- read-across source
Reference
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is a strong acid (pH ≤ 2.0) or base (pH ≥ 11.5) and the available information indicates that it should be classified as skin corrosion (Category 1, 1A, 1B or 1C)
- Justification for type of information:
- Dissociation constants pKa for phosphonic acid in water has been reported in literature 1,80 and 6,20 from Dissociation constants of certain phosphorous-containing acids in aliphatic alcohols; Kreshkov A (1966) Russian Journal of Physical Chemistry vol 40 no 9.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
