Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 500-744-0 | CAS number: 162492-10-6 1 - 6.5 moles propoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016-11-02 to 2017-
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- sewage, predominantly domestic, non-adapted
- Details on inoculum:
- The inoculum was obtained on 22 November 2016 from the activated sludge of the biological wastewater treatment plant from Mourenx (France, 64) which handles predominantly domestic sewage.
On arrival at the laboratory, the sludge (around 2.5 L) was centrifuged at approximately 20°C for 10 min at 1000 g; the solid sewage inoculant portion was re-suspended in dilution water in order to keep the concentration unchanged with respect to the sample. The inoculum was preconditioned 48 hours (aeration) until the flasks were inoculated.
Sub-samples of the homogenised sludge were dried in an oven at approximately 105°C and the suspended solids content was determined to be 4.29 g/L.
The inoculum was not adapted to the test item before the biodegradation test. - Duration of test (contact time):
- 56 d
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- A total of 9 bioreactors were used; 2 each for test item, blank control, reference item control, emulsifying agent control and one for toxicity control.
- Reference substance:
- benzoic acid, sodium salt
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 64.1
- Sampling time:
- 28 d
- Remarks on result:
- other: Not considering nitrification; Not passing 10d window criterion
- Parameter:
- % degradation (O2 consumption)
- Value:
- 56.6
- Sampling time:
- 28 d
- Remarks on result:
- other: Considering the occurrence of nitrification
- Parameter:
- % degradation (O2 consumption)
- Value:
- 87.8
- Sampling time:
- 56 d
- Remarks on result:
- other: Not considering nitrification
- Parameter:
- % degradation (O2 consumption)
- Value:
- 77.5
- Sampling time:
- 56 d
- Remarks on result:
- other: Considering the occurrence of nitrification
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable, but failing 10-day window
- Conclusions:
- According to the OECD 301 guideline, the pass levels for ready biodegradability is 60% of ThOD for respirometric methods. This pass value has to be reached in a 10-d window within the 28-d period of the test; the 10-d window begins when the degree of biodegradation has reached 10% ThOD and must end before day 28 of the test.
In this study the, 10% biodegradation of ThOD starts at day 12 and the biodegradation reached the pass level 60% of ThOD between day 28 (without nitrification) and day 29 if considering nitrification (i.e. > 10 days). Consequently, the test item Glycerol, propoxylated, esters with acrylic acid, reaction products with diethylamine was not readily biodegradable under the conditions of the test. - Executive summary:
The study was conducted in accordance with procedures outlined in OECD Guideline 301F (1992). The ready biodegradability ofGlycerol, propoxylated, esters with acrylic acid, reaction products with diethylamine was assessed over a 56 days period (in the absence of the CHN analysis at Day 28, the test was extended until Day 56 as the test item biodegradation was close to the pass level (60%) at Day 28).
The test was conducted at a nominal loading rate of 100 mg/L. As test item was suspected to be difficult to dissolve, its dispersibility was improved by use of an emulsifying agent (Symperonic P103) as described in ISO 10634 standard.
A total of 9 bioreactors were used; 2 each for test item, blank control, reference item control, emulsifying agent control and one for toxicity control.
The time to reach the different biodegradation levels is detailed in the table below:
Biodegradation level
Without nitrification
With nitrification
Replicate 1 (Ft1)
Replicate 2 (Ft2)
Average
Replicate 1 (Ft1)
Replicate 2 (Ft2)
Average
10%
Day 11
Day 13
Day 12
Day 11
Day 13
Day 12
60%
Day 17
Day 30
Day 28
Day 20
Day 35
Day 29
10-D window success
Yes
No
No
Yes
No
No
The test item was not readily biodegradable under the conditions of the test as it failed to achieve a transition from 10% to 60% degradation in a 10-day window during the 28 days test.
The test item was not considered to be inhibitory to the microbial inoculum since the biodegradation observed in the toxicity control bioreactor was not less than 25% occurred within 14 days.
The definitive test met the validity criteria of the test guideline detailed as follows:
§ the difference of extremes of replicate values of the removal of the test item at the end of the extended period (i.e. 56 days) was less than 20%
§ the percentage degradation of the reference compound has reached the pass levels by day 14: 91.3% (with or without nitrification)
§ the biodegradation observed in the toxicity control bioreactor was not less than 25% occurred within 14 days: 44.2% (without nitrification) and 44.1 % (with nitrification)
§ the oxygen uptake of the inoculum blank was not greater than 60 mg/l in 56 days: 20.6 mg/L (blank control) and 36.3% (emulsifying control)
§ the pH value was not outside the 6 -8.5 range: min 7.2, max 7.7
The test is thus considered as valid.
Reference
Theoretical Oxygen Demand
The theoretical oxygen demand of the test item is ThODNH4 = 2.0588 mg O2/mg (based on CHN analysis). This calculation does not take into account any other constituents/impurities within the substance as supplied and is calculated by assuming formation of ammonium, water and carbon dioxide (no nitrification). If considering nitrification, ThODNO3 = 2.3330 mg O2/mg.
Description of key information
In a screening biodegradation test performed according to OECD Test Guideline 301F, the test substance Glycerol, propoxylated, esters with acrylic acid, reaction products with diethylamine (CAS 162492-10-6) reached a biodegradation level of 64.1% at Day 28 (considering no nitrification), but the 10-day window criterion was not passed. As the validity criteria were fulfilled, the test substance is considered as readily biodegradable but failing the 10-day window criterion.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable but failing 10-day window
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.