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EC number: 500-744-0 | CAS number: 162492-10-6 1 - 6.5 moles propoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2017-07-20
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- According to chapter R.7a of the ECHA Guidance on information requirements and chemical safety assessment (version 2.0, November 2014), as the test substance is manufactured at more than 10 and less than 100 tons a year and as the test substance is not a surfactant, the Koc should be calculated as a first step.
The minimum and maximum values for molecular weight are the following:
Training Set Molecular Weights:
Minimum MW: 32.04
Maximum MW: 665.02
Average MW: 224.4
Validation Molecular Weights:
Minimum MW: 73.14
Maximum MW: 504.12
Average MW: 277.8
Currently there is no universally accepted definition of model domain. However, users may wish to consider the possibility that log Koc estimates are less accurate for compounds outside the MW range of the training set compounds, and/or that have more instances of a given fragment than the maximum for all training set compounds. It is also possible that a compound may have a functional group(s) or other structural features not represented in the training set, and for which no fragment coefficient or correction factor was developed. These points should be taken into consideration when interpreting model results. - Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The Koc was determined by using a QSAR (KOCWIN v2.00 EPI SUITE 2000 U.S. Environmental Protection Agency) recommended by ECHA.
- Key result
- Type:
- Koc
- Value:
- >= 282.7 - <= 520 300 L/kg
- Remarks on result:
- other: Molecular Connectivity Index (MCI) method
- Key result
- Type:
- log Koc
- Value:
- >= 2.45 - <= 5.71 dimensionless
- Executive summary:
The adsorption/desorption coefficients of the following components of the test substance were estimated by using the QSAR model KOCWIN v2.00 via the MCI method:
• Glycerol (PO)0 with 0 DEA
• Glycerol (PO)5 with 0 DEA
• Glycerol (PO)0 with 3 DEA
• Glycerol (PO)5 with 3 DEA
The log Koc values obtained were:
• Glycerol (PO)0 with 0 DEA: 2.4513
• Glycerol (PO)5 with 0 DEA: 3.3063
• Glycerol (PO)0 with 3 DEA: 4.8612
• Glycerol (PO)5 with 3 DEA: 5.7162
The Koc values obtained were:
• Glycerol (PO)0 with 0 DEA: 282.7 L/kg
• Glycerol (PO)5 with 0 DEA: 2025 L/kg
• Glycerol (PO)0 with 3 DEA: 72650 L/kg
• Glycerol (PO)5 with 3 DEA: 520300 L/kg
The log Koc range of Glycerol propoxylated, esters with acrylic acid, reaction products with diethylamine was thus estimated to be between 2.45 and 5.72.
Reference
Description of key information
The range of adsorption/desorption coefficients of Glycerol propoxylated, esters with acrylic acid, reaction products with diethylamine (CAS 162492-10-6) was estimated using the recommended QSAR model KOCWIN v2.00 from the MCI method.
The estimated log Koc values were in the 2.45 – 5.72 range and the Koc values were between 282.7L/kg and 520300L/kg.
Key value for chemical safety assessment
- Koc at 20 °C:
- 520 300
Additional information
As a conservative approach, the highest Koc and log Koc values obtained (Glycerol (PO)5 with 3 DEA) were selected for the chemical safety assessment of this substance.
[LogKoc: 5.72]
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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