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EC number: 234-421-8 | CAS number: 12003-13-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The acute dermal toxicity study indicated that titanium trichloride was serious corrosive to the skin.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation / corrosion, other
- Remarks:
- Acute dermal toxicity study
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1997
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 402 Acute dermal toxicity
- Deviations:
- not specified
- GLP compliance:
- no
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Wako pure chemical industry Co., Ltd. 20wt% hydrochloric acid solution. - Species:
- rat
- Strain:
- Wistar
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Japan LSC
- Age at study initiation: 11 week
- Weight at study initiation: not known
- Housing:Metal mesh cage w220 x D220 x H170 mm
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum):ad libitum
- Acclimation 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 24±1°C
- Humidity (%): 55 ± 5 %
- Air changes (per hr): 18 times/hr
- Photoperiod (hrs dark / hrs light):12 hrs dark/ 12 hrs light
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- other: aqueous hydrochloride solution
- Controls:
- no
- Amount / concentration applied:
- 500, 1000 and 2000 mg/kg
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 14 days
- Number of animals:
- Not specified
- Details on study design:
- TEST SITE
- Area of exposure: back 9 x 6 cm
- % coverage: 10 % of body surface area calculated from (0.1 x body weight) ^2/3
- Type of wrap if used: aluminum foil, transparent dressing tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): after 24 hours, applied port was washed with warm water to remove test substance completely.
- Time after start of exposure:24 hours
OBSERVATION TIME POINTS
(indicate if minutes, hours or days) 24 hours, 2nd day, 5th day - Irritation parameter:
- other: corrosive
- Basis:
- animal:
- Time point:
- 24 h
- Reversibility:
- not reversible
- Remarks on result:
- probability of severe irritation
- Remarks:
- contact ports were seriously corroded.
- Irritation parameter:
- other: corrosive
- Basis:
- animal:
- Time point:
- 48 h
- Reversibility:
- not reversible
- Remarks on result:
- other: change colour and eschar formation
- Remarks:
- Corroded port was changed its colour to brown and eschar formation began.
- Irritation parameter:
- other: corrosive
- Basis:
- animal:
- Time point:
- other: 5th day
- Reversibility:
- not reversible
- Remarks on result:
- other: Eschar separation
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- Tttanium trichloride solution was very corrosive to the skin.
- Executive summary:
In the acute dermal toxicity study, this substance showed very corrosive property to the skin.
So, skin corrosion/irritation study was not carried out.
This material is corrosive to the skin.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation, other
- Remarks:
- In the acute dermal toxicity study, serious corrosive effect was observed.
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study need not be conducted because the available information indicates that the criteria are met for classification as corrosive to the skin or irritating to eyes
- Reason / purpose for cross-reference:
- reference to other study
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
The acute dermal toxicity study indicated that titanium tirchloride was serious corrosive to skin.
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