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EC number: 234-421-8 | CAS number: 12003-13-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003-12-18 to 2004-02-06
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Version / remarks:
- December 17, 2001
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Titanium trichloride
- EC Number:
- 231-728-9
- EC Name:
- Titanium trichloride
- Cas Number:
- 7705-07-9
- Molecular formula:
- Cl3Ti
- IUPAC Name:
- Titanium trichloride Titanium(III) trichloride
- Reference substance name:
- unknown impurities
- IUPAC Name:
- unknown impurities
- Test material form:
- solid: granular
- Details on test material:
- Purity: 99.6%
Constituent 1
impurity 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material:Tosoh FInechem Corp., Lot No,;THP1031
- concentration: 0.3 and 0.5 wt% in olive olil.
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material:Stable under inert atmosphere.
- Stability under test conditions:Not known
- Solubility and stability of the test substance in the solvent/vehicle:Not known
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles river Japan
- Females (if applicable) nulliparous and non-pregnant: [yes/no] Yes
- Age at study initiation: 8 weeks
- Weight at study initiation: 211 g (207,1 - 218.6 g)
- Fasting period before study: Overnight
- Housing:Stainless steel net floor cages (260W x 300D x 150H mm)
- Diet (e.g. ad libitum): ad libitumm
- Water (e.g. ad libitum):ad libitu
- Acclimation period:9 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 - 25
- Humidity (%): 40 - 70 %
- Air changes (per hr): 10 - 15
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 2004-01-06 To:2004-01-29
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 0.5 and 3.0%
- Amount of vehicle (if gavage):10 mL/kg
- Justification for choice of vehicle:good dispesion property
- Lot/batch no. (if required):
- Purity: - Doses:
- 50 mg/kg, 300 mg/kg
- No. of animals per sex per dose:
- Female 5 per gruop
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:observation; 10 min, 30min, 1h, 2h, 3h and 4 h on administration day. Twice on the next day. after that observation was conducted once a day until 14th day after administration.
Weighing: 1,7,14 day
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology - Statistics:
- not used
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Both groups (50 mg/kg and 300 mg/kg) did not show death after single oral treatment during whole (14 days post-treatment period) experiment. (Tabel 1)
- Clinical signs:
- 10 minutes after administration of substance, all animals in 300 mg/kg showed decreased spontaneous locomotion and three of them showed decreased respiratory rate and incomplete eyelid opening. These symptoms became to disapear after 3 hours and completely disappeared after one day. In addition, one animal in 50 mg/kg group showed mucous stool.
This mucous stool was transient change after administration. As this symptom was sometimes observed by administration of olive oil, this observation was seemed to be due to administration of medium (olive oil). - Body weight:
- all animals showed expected gains in body weight.
- Gross pathology:
- No abnormalities were observed at necropsy.
Any other information on results incl. tables
Table 1 Acute oral toxicity study in rats
Mortality
Sex |
Exp group |
Number of deaths on day |
Mortality |
|||||||||||||||||||||
0 |
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
14(day) |
||||||||||
0a) |
5 |
10 |
30 (min) |
1 |
2 |
3 |
4(h) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||
Female |
50 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0/5b) |
300 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0/5b) |
a) Immediately after administration
b) Number of dead animals/Number of animals
Table 2 Acute oral toxicity study in rats
Summary of clinical signs
Signs |
Female |
|||
50 |
300 |
mg/kg |
||
ta |
ta |
|
|
|
5a) |
5 |
|
|
|
No abnormalities detected |
4 |
|
|
|
Decreased spontaneouslocmotion |
|
5 |
|
|
Decreased respiratory rate |
|
3 |
|
|
Incomplete eyelid opening |
|
3 |
|
|
Mucous stool |
1 |
|
|
|
ta, terminal autopsy
a) Number of animals examined
Table 3 Acute oral toxicity study in rats
Summary of body weights (g)
Sex |
Exp. Group |
Number of |
Observation period |
|||||
0 |
1 |
7 |
14 |
(day) |
||||
Female |
50 |
5 |
188.4 |
210.4 |
230.5 |
247.5 |
|
|
±2.3 |
±3.5 |
±13.5 |
±17.5 |
|
|
|||
300 |
5 |
192.7 |
207.6 |
231.6 |
254.1 |
|||
±4.6 |
±5.4 |
±4.2 |
±10.9 |
|
|
Mean ± S.D.
Table 4 Acute oral toxicity study in rats
Summary of macroscopic examination
Findings |
Female |
|||
50 |
300 |
(mg/kg) |
||
ta |
ta |
|
|
|
5a) |
5 |
|
|
|
No abnormalities detected |
5 |
5 |
|
|
ta, terminal autopsy.
a) Number of animals examined.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- The acute oral median lethal dose (LD50) of the substance in the female rat was estimated to be greater than 300 mg/kg bodyweight.
- Executive summary:
The acute oral median lethal dose (LD50) of the substance in the female rat was estimated to be greater than 300 mg/kg bodyweight.
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