Registration Dossier
Registration Dossier
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Reaction mass of Trisodium 4-({4-chloro-6-[(4-sulfonatophenyl)amino]-1,3,5-triazin-2-yl}amino)-2-{[1-ethyl-2-hydroxy-4-methyl-6-oxo-5-(sulfonatomethyl)-1,6-dihydropyridin-3-yl]diazenyl}benzenesulfonate and Trisodium 4-({4-chloro-6-[(3-sulfonatophenyl)amino]-1,3,5-triazin-2-yl}amino)-2-{[1-ethyl-2-hydroxy-4-methyl-6-oxo-5-(sulfonatomethyl)-1,6-dihydropyridin-3-yl]diazenyl}benzenesulfonate
EC number: 944-218-2 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experiment start date - 29 September 2015; Experiment completion date - 02 October 2015; Study completion date - 05 October 2015.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- Identification: FAT 40000/I TE Lot: MC 13
Appearance: Yellowish-orange powder - Analytical method:
- photometric method
- Type:
- Pow
- Partition coefficient:
- 0
- Temp.:
- 20 °C
- Remarks on result:
- other: pH not available
- Key result
- Type:
- log Pow
- Partition coefficient:
- -5.7
- Temp.:
- 20 °C
- Remarks on result:
- other: pH not available
- Conclusions:
- The n-octanol/water partition coefficient (log Pow) of the test item at 20 °C was determined to be -5.70.
- Executive summary:
The n-octanol/water partition coefficient of the test item was evaluated in a study conducted according to the EU Method A.8, OECD Guideline 107 and OECD Guideline 117. Flask method was used for this purpose.
Based on the findings of the study, the n-octanol/water partition coefficient (log Pow) of test item at 20 °C was determined to be -5.70 (Pow = 1.99E-6).
Reference
Preliminary Visual Estimation of the n-Octanol solubility
10 mg of the test item were stirred with different amounts of n-octanol at room temperature and visually checked for any undissolved particles.
Amount of test item in mg |
Volume in ml |
Total volume in ml |
Stirring time |
Appearance of mixture |
10 |
10 |
10 |
60 min |
undissolved |
10 |
40 |
50 |
60 min |
undissolved |
10 |
50 |
100 |
60 min |
undissolved |
According to this preliminary test the solubility of the test item in n-octanol is below 0.1 g/l (without correction of the purity).
Determination of the solubility in the n-Octanol phase - Flask Method
Experiment |
A |
B |
C |
D (blank) |
Amountof test item (mg) |
1000 |
1000 |
1000 |
-- |
Stirring time at 30°C (h) |
24 |
48 |
72 |
72 |
Measured concentration (µg/ml) |
0.69 |
0.76 |
0.73 |
-- |
Dilution |
--- |
--- |
--- |
-- |
n-Octanol solubility (mg/l) |
0.69 |
0.76 |
0.73 |
-- |
Average experiments A to C: 0.73 mg/l
Description of key information
The n-octanol/water partition co-efficient (log Pow) of FAT 40000 at 20 °C was determined to be -5.70 (Pow = 1.99E-6).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -5.7
- at the temperature of:
- 20 °C
Additional information
The n-octanol/water partition coefficient of the test item was evaluated in a study conducted according to the EU Method A.8, OECD Guideline 107 and OECD Guideline 117. Flask method was used for this purpose.
Based on the findings of the study, the n-octanol/water partition coefficient (log Pow) of test item at 20 °C was determined to be -5.70 (Pow = 1.99E-6).
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