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EC number: 242-828-7 | CAS number: 19125-99-6
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 08/06/2016 - 08/06/2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Experimental test result performed using standard test guidelines
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- GLP compliance:
- not specified
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
- Test temperature:
- 25°C
- Details on study design: HPLC method:
- The solutions of the test substance and reference substances were prepared in the mobile phase. Each of the reference substance and test substance were analysed by HPLC at 210 nm.
After equilibration of the HPLC system, Urea was injected first, the reference substances were injected in duplicate, followed by the test chemical solution in duplicate. Reference substances were injected again after test sample, no change in retention time of reference substances was observed.
Retention time tR were measured, averaged and the decimal logarithms of the capacity factors k were calculated. The graph was plotted between log Koc versus log k(Annex - 2).The linear regression parameter of the relationship log Koc vs log k were also calculated from the data obtained with calibration samples and therewith, log Koc of the test substance was determined from its measured capacity factor. - Details on sampling:
- - Concentrations: 500mg/L
- Sampling interval: No data avaialble
- Sample storage before analysis: No data avaialble - Details on matrix:
- No data
- Details on test conditions:
- No data
- Key result
- Type:
- log Koc
- Value:
- 4.271
- Temp.:
- 25 °C
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The Adsorption Coefficient of test substance 2-butyl-6-(butylamino)-1H-benz[de]isoquinoline-1,3(2H)-dione (CAS No.19125-99-6)was determined as per the HPLC method (OECD Guideline-121). The Log Koc value was found to be 4.271 ± 0.049 at 25°C.
- Executive summary:
The adsorption coefficient Koc in soil and in sewage sludge2-butyl-6-(butylamino)-1H-benz[de]isoquinoline-1,3(2H)-dione(CAS No. 19125-99-6)was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 121 for testing of Chemicals. The reference substances were chosen according to structural similarity with the test substance and calibration graph was prepared. The reference substances were Toluene, Xylene, Ethylbenzene, Naphthalene, 1,2,3 Trichlorobenzene, Phenanthrene and DDT having Kocvalue ranging from 2.369 to 5.63. The Log Kocvalue was found to be 4.271 ± 0.049 at 25°C.
Reference
The Log Kocof2-butyl-6-(butylamino)-1H-benz[de]isoquinoline-1,3(2H)-dione (CAS No. 19125-99-6) was found to be 4.271 ± 0.049 at 25°C.
Reference substance |
Log Koc |
tR1 |
tR2 |
tR3 |
MeantR± S.D. |
k |
Log k |
Urea |
- |
0.887 |
0.887 |
0.888 |
0.887±0.001 |
- |
- |
Toluene |
2.369 |
4.378 |
4.382 |
- |
4.38±0.003 |
3.937 |
0.595 |
Xylene |
2.58 |
6.241 |
6.232 |
- |
6.236±0.006 |
6.031 |
0.78 |
Ethylbenzene |
2.649 |
6.359 |
6.355 |
- |
6.357±0.003 |
6.166 |
0.79 |
naphthalene |
2.75 |
6.127 |
6.218 |
- |
6.172±0.064 |
5.958 |
0.775 |
1,2,3-trichlorobenzene |
3.16 |
9.519 |
9.541 |
- |
9.53±0.016 |
9.744 |
0.988 |
Phenanthrene |
4.09 |
11.996 |
11.779 |
- |
11.887±0.153 |
12.401 |
1.09 |
DDT |
5.63 |
61.125 |
59.008 |
- |
60.066±1.497 |
66.718 |
1.820 |
Test substance 2-butyl-6-(butylamino)-1H-benz[de]isoquinoline-1,3(2H)-dione |
K |
Log k |
Log Koc by Calibration Graph |
Mean of LogKoc± S.D. |
|
tR1 |
19.675 |
21.182 |
1.326 |
4.305 |
4.271 ± 0.049 |
tR2 |
18.642 |
20.017 |
1.301 |
4.236 |
|
Description of key information
The Adsorption Coefficient of test substance 2-butyl-6-(butylamino)-1H-benz[de]isoquinoline-1,3(2H)-dione (CAS No.19125-99-6)was determined as per the HPLC method (OECD Guideline-121). The Log Koc value was found to be 4.271 ± 0.049 at 25°C.
Key value for chemical safety assessment
- Koc at 20 °C:
- 4.271
Additional information
The adsorption coefficient Koc in soil and in sewage sludge2-butyl-6-(butylamino)-1H-benz[de]isoquinoline-1,3(2H)-dione(CAS No. 19125-99-6)was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 121 for testing of Chemicals. The reference substances were chosen according to structural similarity with the test substance and calibration graph was prepared. The reference substances were Toluene, Xylene, Ethylbenzene, Naphthalene, 1,2,3 Trichlorobenzene, Phenanthrene and DDT having Kocvalue ranging from 2.369 to 5.63. The Log Kocvalue was found to be 4.271 ± 0.049 at 25°C.
[LogKoc: 25.0]
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