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Diss Factsheets

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
oxidising solids
Type of information:
experimental study
Adequacy of study:
key study
Study period:
02-07-2007 - 05-07-2007
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods
Justification for type of information:
Experimental data using standard method of analysis
Qualifier:
according to guideline
Guideline:
EU Method A.17 (Oxidising Properties (Solids))
Principles of method if other than guideline:
Determine oxidising properties of the chemical Denatonium Benzoate
GLP compliance:
yes
Specific details on test material used for the study:
- Name of test material (as cited in study report): Denatonium benzoate
- IUPAC NAme : benzyl({[(2,6-dimethylphenyl)carbamoyl]methyl})diethylazanium benzoate hydrate
- Molecular formula: C21H29N2O.C7H5O2
- Molecular weight: 446.58 g/mol
- Smiles : CC[N+](CC)(Cc1ccccc1)CC(=O)Nc2c(cccc2C)C.c1ccc(cc1)C(=O)[O-]
- InChI : 1S/C21H28N2O.C7H6O2/c1-5-23(6-2,15-19-13-8-7-9-14-19)16-20(24)22-21-17(3)11-10-12-18(21)4;8-7(9)6-4-2-1-3-5-6/h7-14H,5-6,15- 16H2,1-4H3;1-5H,(H,8,9)
- Substance type: organic
- Physical state: Solid
Contact with:
powdered cellulose
Key result
Sample tested:
reference mixture as specified
Parameter:
preliminary test
Result:
6 min
Remarks on result:
other: No other detail available
Key result
Sample tested:
other: 10 : 90, Sample/Cellulose
Parameter:
preliminary test
Result:
4 min
Remarks on result:
other: No other detail available
Key result
Sample tested:
other: 30 : 70, Sample/Cellulose
Parameter:
preliminary test
Result:
4 min
Remarks on result:
other: No other detail available
Key result
Sample tested:
other: 50 : 50, Sample/Cellulose
Parameter:
preliminary test
Result:
2.5 min
Remarks on result:
other: No other detail available
Key result
Sample tested:
other: 70 : 30, Sample/Cellulose
Parameter:
preliminary test
Result:
3.25 min
Remarks on result:
other: No other detail available
Key result
Sample tested:
other: 90 : 10, Sample/Cellulose
Parameter:
preliminary test
Result:
15.33 min
Remarks on result:
other: No other detail avilable

In all cases except the last (i.e. 90: 10, Sample/Cellulose), the reaction was vigorous, with a lot of black smoke and, as can be seen, a total reaction time faster than the reference Mixture.

In the case of the 90: 10, Sample/Cellulose, the sample melted when heated and thjs appeared to cause the reaction to slow significantly, to such an extent that the total reaction time was then much longer than the reference Material.

ln order to assess whether the result obtained might be a false positive, the mixture with the fastest reaction speed (i.e. 50 : 50, Sample/Cellulose) was prepared us ing an inert material (Kieselguhr) in place of the Cellulose.

Hence, duplicate tests with the train were carried out using a previously dried and sieved, 1 : 1 mixture of sample with Kieselguhr, prepared as for the Cellulose. It was fow1d that these were even more vigorous than those with the Cellulose giving reaction times for between the 30mm and 230mm marks of I 11Unute and I minute 30 seconds respectively (cf. 2 minutes 30 seconds with Cellulose.

There therefo re seems little doubt that the original results were NOT a false positive and that indeed Denatonjum Benzoate, by virtue of its faster reaction times at almost all ratios with Cellulose, must be considered as an Oxidising Substance.

Interpretation of results:
other: Oxidising substance
Conclusions:
Based on the experimental result, it is concluded that Denatonium Benzoate is an oxidising substance. By virtue of its faster reaction times at almost all ratios with Cellulose, must be considered as an Oxidising Substance.
Executive summary:

Oxidising property of the chemical Denatonium benzoate was determined in accordance with EEC Method A 17.

Based on the experimental result, it is concluded that Denatonium Benzoate is an oxidising substance. By virtue of its faster reaction times at almost all ratios with Cellulose, must be considered as an Oxidising Substance.

Description of key information

Based on the experimental result, it is concluded that Denatonium Benzoate is an oxidising substance. By virtue of its faster reaction times at almost all ratios with Cellulose, must be considered as an Oxidising Substance.

Key value for chemical safety assessment

Oxidising properties:
oxidising

Additional information

Oxidising property of the chemical Denatonium benzoate was determined in accordance with EEC Method A 17.

Based on the experimental result, it is concluded that Denatonium Benzoate is an oxidising substance. By virtue of its faster reaction times at almost all ratios with Cellulose, must be considered as an Oxidising Substance.

Justification for classification or non-classification

Oxidising property of the chemical Denatonium benzoate was determined in accordance with EEC Method A 17.

Based on the experimental result, it is concluded that Denatonium Benzoate is an oxidising substance. By virtue of its faster reaction times at almost all ratios with Cellulose, must be considered as an Oxidising Substance.