Registration Dossier

Administrative data

Key value for chemical safety assessment

Effects on fertility

Effect on fertility: via oral route
Endpoint conclusion:
no study available
Effect on fertility: via inhalation route
Endpoint conclusion:
no adverse effect observed
Effect on fertility: via dermal route
Endpoint conclusion:
no study available
Additional information

A data waiving is claimed for toxicity to reproduction for HDI oligomers, isocyanurate type. A full and detailed text elaborating the data waiving is attached to this endpoint summary.


Justification for selection of Effect on fertility via inhalation route:
No definite reproductive toxicity study is available for the substance. Based on read-across two reproductive toxicity screenings are available, but none is selected here, since both are considered relevant for assessment.

Effects on developmental toxicity

Effect on developmental toxicity: via oral route
Endpoint conclusion:
no study available
Effect on developmental toxicity: via inhalation route
Endpoint conclusion:
no adverse effect observed
Effect on developmental toxicity: via dermal route
Endpoint conclusion:
no study available
Additional information

A data waiving is claimed for developmental toxicity for HDI oligomers, isocyanurate type. A full and detailed text elaborating the data waiving is attached to this endpoint summary.


Justification for selection of Effect on developmental toxicity: via oral route:
Inhalation is the relevant route of exposure during use.

Justification for selection of Effect on developmental toxicity: via inhalation route:
No study is selected, since three fully reliable developmental toxicity studies are available based on read across, and are all considered relevant for assessment.

Justification for selection of Effect on developmental toxicity: via dermal route:
Inhalation is the relevant route of exposure during use.

Justification for classification or non-classification

According to Regulation (EC) No 1272/2008, Annex I, no classification is warranted for toxicity to reproduction.