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EC number: 237-898-0 | CAS number: 14059-33-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Bismuth vanadium tetraoxide
- EC Number:
- 237-898-0
- EC Name:
- Bismuth vanadium tetraoxide
- Cas Number:
- 14059-33-7
- Molecular formula:
- Bi O4 V
- IUPAC Name:
- vanadium(5+) bismuth(3+) tetraoxidandiide
- Details on test material:
- - Name of test material (as cited in study report): Bismuth Vanadate
- Molecular formula (if other than submission substance): BiVO4
- Molecular weight (if other than submission substance): 323.92
- Physical state: yellow powder
- Analytical purity: >99.5% w/w
- Impurities (identity and concentrations): water and others, <0.5% w/w
- Lot/batch No.: BVB-1018
- Stability under test conditions: stable
- Other: melting point>800°C
Constituent 1
Method
- Target gene:
- bacterial reverse mutation assay
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and E. coli WP2
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9-mix from treated SD rats
- Test concentrations with justification for top dose:
- 50, 100, 200, 500, 1000, 2000 and 5000 µg/plate in the first experiment (dose selection) and 313, 625, 1250, 2500 and 5000 µg/plate in the econdt experiment
- Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: DMSO
- Justification for choice of solvent/vehicle: solubility
Controls
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- Positive controls:
- yes
- Positive control substance:
- other: 2AA for all strains with S9-mix; AF-2for TA100, WP2 uvrA and TA98, NaN3 for TA1535 and ICR-191 for TA1537 without S9-mix
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: preincubation
DURATION
- Preincubation period: 20 min
- Incubation: 48 hours
DETERMINATION OF CYTOTOXICITY
- Method: cloning efficiency - Evaluation criteria:
- not reported
- Statistics:
- not reported
Results and discussion
Test results
- Species / strain:
- other: S. typhimurium TA 1535, TA 1537, TA 98 and TA 100 and E. coli WP2 uvrA
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Remarks:
- Because there was no increase in the colony number of reverse mutation for every strain, comparing with negative control, we concluded that the mutagenicity of this test substance is negative (see Table 1&2)
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Remarks:
- the test substance was tested up to 5000 µg/plate
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- Positive controls validity:
- valid
- Additional information on results:
- - Solubility of the test substance was less than 5 w/v % in water and DMSO and less than 10 w/v % in acetone (measured at this test institute)
- We selected DMSO as the solvent, because it made more stable suspension than water and acetone.
- We observed yellow precipitation of the test substance above 625 µg/plate without S9-mix and 313 µg/plate with S9-mix. But there was no obstacle to count the colony number of reverse mutation.
Any other information on results incl. tables
Table 1; first experiment: Dose selection result
With(+) or without (-) S9-mix |
Test substance concentration (mg/plate |
Mean number of revertants (number of colonies/plate; triplicate) |
|||||
Based-pair substitution type |
Frameshift type |
||||||
TA100 |
TA1535 |
WP2 uvrA |
TA98 |
TA1537 |
|||
|
Solvent control |
102 |
9 |
24 |
25 |
10 |
|
50 |
120 |
11 |
32 |
19 |
10 |
||
100 |
113 |
10 |
22 |
20 |
12 |
||
200 |
120 |
10 |
23 |
23 |
13 |
||
500 |
112 |
14 |
22 |
20 |
10 |
||
1000 |
103 |
10 |
23 |
20 |
8 |
||
2000 |
109 |
10 |
19 |
20 |
11 |
||
5000 |
99 |
11 |
19 |
22 |
10 |
||
|
Solvent control |
109 |
12 |
29 |
32 |
22 |
|
50 |
115 |
8 |
35 |
43 |
18 |
||
100 |
107 |
13 |
35 |
33 |
14 |
||
200 |
102 |
10 |
36 |
31 |
20 |
||
500 |
109 |
12 |
26 |
37 |
15 |
||
1000 |
117 |
10 |
29 |
32 |
21 |
||
2000 |
101 |
13 |
30 |
25 |
18 |
||
5000 |
114 |
13 |
28 |
40 |
18 |
||
Pos. Ctrl |
Without S9-mix |
Name |
AF-2 |
NaN3 |
AF-2 |
AF-2 |
ICR-191 |
Concentration (µg/plate |
0.01 |
0.5 |
0.01 |
0.1 |
0.1 |
||
Mean number of colonies/plate |
446 |
283 |
203 |
507 |
2178 |
||
With S9-mix |
Name |
2AA |
2AA |
2AA |
2AA |
2AA |
|
Concentration (µg/plate |
1 |
2 |
10 |
0.5 |
2 |
||
Mean number of colonies/plate |
520 |
160 |
580 |
163 |
135 |
Table 2; second experiment: Dose selection result
With(+) or without (-) S9-mix |
Test substance concentration (mg/plate |
Mean number of revertants (number of colonies/plate; triplicate) |
|||||
Based-pair substitution type |
Frameshift type |
||||||
TA100 |
TA1535 |
WP2 uvrA |
TA98 |
TA1537 |
|||
S9-mix (-) |
Solvent control |
114 |
10 |
27 |
24 |
14 |
|
313 |
117 |
12 |
32 |
22 |
13 |
||
625 |
123 |
9 |
23 |
24 |
15 |
||
1250 |
134 |
11 |
22 |
27 |
13 |
||
2500 |
116 |
10 |
27 |
20 |
13 |
||
5000 |
129 |
9 |
22 |
24 |
14 |
||
S9-mix (+)
|
Solvent control |
111 |
10 |
30 |
30 |
21 |
|
313 |
126 |
11 |
38 |
37 |
26 |
||
625 |
133 |
10 |
38 |
35 |
28 |
||
1250 |
128 |
11 |
39 |
36 |
27 |
||
2500 |
127 |
9 |
33 |
37 |
20 |
||
5000 |
117 |
10 |
31 |
34 |
25 |
||
Pos. Ctrl |
Without S9-mix |
Name |
AF-2 |
NaN3 |
AF-2 |
AF-2 |
ICR-191 |
Concentration (µg/plate |
0.01 |
0.5 |
0.01 |
0.1 |
0.1 |
||
Mean number of colonies/plate |
515 |
282 |
532 |
2572 |
2178 |
||
With S9-mix |
Name |
2AA |
2AA |
2AA |
2AA |
2AA |
|
Concentration (µg/plate |
1 |
2 |
10 |
0.5 |
2 |
||
Mean number of colonies/plate |
545 |
129 |
601 |
190 |
130 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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