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EC number: 237-898-0 | CAS number: 14059-33-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 407 (Repeated Dose 28-Day Oral Toxicity Study in Rodents)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Bismuth vanadium tetraoxide
- EC Number:
- 237-898-0
- EC Name:
- Bismuth vanadium tetraoxide
- Cas Number:
- 14059-33-7
- Molecular formula:
- Bi O4 V
- IUPAC Name:
- vanadium(5+) bismuth(3+) tetraoxidandiide
- Details on test material:
- - Name of test material (as cited in study report): Bismuth Vanadate
- Molecular formula (if other than submission substance): BiVO4
- Molecular weight (if other than submission substance): 323.92
- Physical state: yellow powder
- Analytical purity: >99.5% w/w
- Impurities (identity and concentrations): water and others, <0.5% w/w
- Lot/batch No.: BVB-1018
- Stability under test conditions: stable
- Other: melting point>800°C
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Remarks:
- Crj
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- not reported
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 5% arabia Gum aqueous solution
- Details on oral exposure:
- PREPARATION OF DOSING SOLUTIONS:
not reported - Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 28 days
- Frequency of treatment:
- daily
Doses / concentrationsopen allclose all
- Dose / conc.:
- 40 mg/kg bw/day (actual dose received)
- Dose / conc.:
- 200 mg/kg bw/day (actual dose received)
- Dose / conc.:
- 1 000 mg/kg bw/day (actual dose received)
- No. of animals per sex per dose:
- 6 (12 in the control and 12 in the highest dose groups, 6 each as satellite)
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- - Dose selection rationale: preliminary 14-day feeding test was conducted (4 animals each sex per group receiving 50, 250 and 1000 mg/kg bw), whre the NOAEL was found to be the highest dose level tested
- Rationale for selecting satellite groups: recovery (additional control und highest dose level groups)
- Post-exposure recovery period in satellite groups: 14 days - Positive control:
- not conducted
Examinations
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: Yes
- Time schedule: not reported
DETAILED CLINICAL OBSERVATIONS: Yes
- Time schedule: at termination
BODY WEIGHT: Yes
- Time schedule for examinations: at days -3, 1, 3, 5, 8, 10 and 12
FOOD CONSUMPTION:
- Food consumption for each animal determined and mean daily diet consumption calculated as g food/kg body weight/day: Yes
OPHTHALMOSCOPIC EXAMINATION: No
HAEMATOLOGY: Yes
- Time schedule for collection of blood: at termination and at the end of the recovery period
- Anaesthetic used for blood collection: No data
- Animals fasted: No data
- How many animals: 6
- Parameters examined: RBC, WBC, Hb, Ht, MCV, MCHC, Platelet, reticulocytes, PT, APTTleucocytes differenciation (N-band, N-Seg, Eosino, Baso, Lymp, Mono)
CLINICAL CHEMISTRY: Yes
- Time schedule for collection of blood: at termination and at the end of the recovery period
- Animals fasted: No data
- How many animals: 6
- Parameters examined: GOT, GPT, ALP, ChE, λ-GTP, T-Cho, TG, glucose, T-ptotein, albumin, A/G ratio, creatinine, BUN, T-Bil, Ca, IP, Na, K and Cl
URINALYSIS: Yes
- Time schedule for collection of urine: at termination and at the end of the recovery period
- Metabolism cages used for collection of urine: No data
- Animals fasted: No data
- Parameters examined: volume, color, pH, protein, ketones, bilirubin, occult blood, glucose and urobilinogen
NEUROBEHAVIOURAL EXAMINATION: No - Sacrifice and pathology:
- GROSS PATHOLOGY: Yes, gross pathology/ organ weight (absolute and relative; spleen, liver, kidney, brain, testis, adrenal gland, ovary)
HISTOPATHOLOGY: Yes; skin, liver, spleen, heart, kidney, forestomach, duodenum, jejunum, ileum, cecum, colon rectum, ovary, adrenal, skin, - Other examinations:
- not applicable
- Statistics:
- not specified
Results and discussion
Results of examinations
- Description (incidence and severity):
- non reversible effects: yellowish brown stool in all animals in the 200 and 1000 mg/kg group.
Reversible in the satellite group: loss of hair and exudate (neck) in one female and one male animals, respectively in the lowest and in the highest dose group; scab formation in one male animal of the highest dose level. - Body weight and weight changes:
- no effects observed
- Description (incidence and severity):
- no difference to the control group in all tested groups.
- Food consumption and compound intake (if feeding study):
- no effects observed
- Description (incidence and severity):
- no difference to the control group in all tested groups.
- Description (incidence and severity):
- compared to the control groups, only the diffenciation of leucocyte - N-Band (%) was higher in the highest dose level, but not different in the satellite group.
- Clinical biochemistry findings:
- no effects observed
- Description (incidence and severity):
- no difference to the control group in all tested groups.
- Urinalysis findings:
- no effects observed
- Description (incidence and severity):
- no difference to the control group in all tested groups.
- Description (incidence and severity):
- reduced ovary weight in the highest dose of the satellite group
- Description (incidence and severity):
- Pelvic dilatation, blackish region of mucosa, skin exudate and scab formation were observed respectively in one female of the lowest dose group, one female of the highest dose group, one male of the lowest dose group and one female of the highest dose group. Only the blakish region of mucose was still present in 3 females of the highest dose recovery group.
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Description (incidence and severity):
- Cyst formation (kidney) in one lowest dose female animal; pelvic dilatation (kidney) in one intermadiate dose male animals; necrosis mucosa (glandular stomach) in 4 (3 satellite) highest dose female animals; skin inflammation and necrosis in two animals, each one male of the lowest and highest dose group.
Effect levels
- Dose descriptor:
- NOEL
- Effect level:
- 200 mg/kg bw/day (actual dose received)
- Sex:
- male/female
- Basis for effect level:
- other: necrosis of glandular stomach, female animals of highest dose only
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
The NOEL is 200 mg/kg bw/day, based on necrosis at glandular stomach observed in female animals at the highest dose group.
Applicant's summary and conclusion
- Conclusions:
- The NOEL is 200 mg/kg bw/day, based on necrosis at glandular stomach observed in female animals at the highest dose group.
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