Registration Dossier
Registration Dossier
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EC number: 202-180-8 | CAS number: 92-70-6
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Abstract information in OECD SIDS report of 2004; study described in OECD SIDS as valid with restrictions as only 10 animals used per dose group.
Data source
Reference
- Reference Type:
- publication
- Title:
- SIDS Initial Assessment Report For SIAM 19 - 3-Hydroxy-2-naphthoic acid
- Author:
- Anonymous
- Year:
- 2 004
- Bibliographic source:
- UNEP Publications
- Report date:
- 2004
Materials and methods
- Principles of method if other than guideline:
- Method described as OECD 406 in OECD SIDS
- GLP compliance:
- not specified
- Type of study:
- guinea pig maximisation test
Test material
- Reference substance name:
- 3-hydroxy-2-naphthoic acid
- EC Number:
- 202-180-8
- EC Name:
- 3-hydroxy-2-naphthoic acid
- Cas Number:
- 92-70-6
- Molecular formula:
- C11H8O3
- IUPAC Name:
- 3-hydroxy-2-naphthoic acid
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal and epicutaneous
- Vehicle:
- other: paraffin (induction) and vaseline (challenge)
- Concentration / amount:
- 2 % active substance intracutaneous (induction)
.25 % active substance occlusive epicutaneous (challenge)
Challengeopen allclose all
- Route:
- epicutaneous, semiocclusive
- Vehicle:
- other: paraffin (induction) and vaseline (challenge)
- Concentration / amount:
- 2 % active substance intracutaneous (induction)
.25 % active substance occlusive epicutaneous (challenge)
- No. of animals per dose:
- 10 for test group
5 for control group
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Group:
- test chemical
- Dose level:
- 0.25%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- no adverse findings reported
- Remarks on result:
- other: Group: test group. Dose level: 0.25%. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: no adverse findings reported.
- Group:
- negative control
- Dose level:
- 0.25%
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Remarks on result:
- other: Group: negative control. Dose level: 0.25%. No with. + reactions: 0.0. Total no. in groups: 5.0.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
