Registration Dossier
Registration Dossier
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EC number: 202-180-8 | CAS number: 92-70-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Abstract information in OECD SIDS report of 2004; study described in OECD SIDS as valid with restrictions because of poor documentation and low number of animals.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- SIDS Initial Assessment Report For SIAM 19 - 3-Hydroxy-2-naphthoic acid
- Author:
- Anonymous
- Year:
- 2 004
- Bibliographic source:
- UNEP Publications
Materials and methods
- Principles of method if other than guideline:
- 1 animal/dose level. Occlusive treatment (rubber cuff and gum pads). 24 hours exposure.
- GLP compliance:
- no
- Test type:
- other: no data
- Limit test:
- no
Test material
- Reference substance name:
- 3-hydroxy-2-naphthoic acid
- EC Number:
- 202-180-8
- EC Name:
- 3-hydroxy-2-naphthoic acid
- Cas Number:
- 92-70-6
- Molecular formula:
- C11H8O3
- IUPAC Name:
- 3-hydroxy-2-naphthoic acid
Constituent 1
Test animals
- Species:
- guinea pig
Administration / exposure
- Type of coverage:
- occlusive
- Duration of exposure:
- 24h
- Doses:
- 5; 10; 20 cc/kg (appr. 500; 1000; 2000 mg/kg bw) as a 10 % solution in vehicle
- No. of animals per sex per dose:
- 1
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 - < 2 000 mg/kg bw
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
