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EC number: 201-545-9
CAS number: 84-61-7
was conducted based on the results given in a previous study(De
Rijke and Willems, CIVO report no. R5228 1977).
The test material
was fed at levels of 0, 0.075, 0.1, 0.15 and1% in stock diet to groups
of ten males and nen females each.
were made of general appearance and behaviour, growth, food intake and
efficiency, and alkaline phosphatase activity in blood plasina. At the
end of the experimental period all rats were killed and examined
grossly.Liver, kidneys and thyroid of all animals were weighed and
samples were taken for histopathological examination.
body weight, food intake and food efficiency were decreased at 1% in
males,Alkaline phosphatase activity in blood plasma was increased at I %
in both sexes. Relative
liver weights were statistically significantly increased in both sexes
at 1% only. Histopathological
examination revealed minimal, though clearly treatment related,changes
in the liver of animals at the I % level.
the results of the present study it was concluded that 0.15 % was a
no-effect level, which is approximately equivalent with a daily intake
of 75 mg /kg body weight.
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