Registration Dossier
Registration Dossier
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EC number: 273-282-8 | CAS number: 68955-56-6
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- repeated dose toxicity: dermal
- Data waiving:
- exposure considerations
- Justification for data waiving:
- other:
Data source
Materials and methods
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Executive summary:
C36-alkylenediaminehas proven to be severely irritating to skin showing to beirreversible within the 14-day observation period, and corrosive to the eyes. Following these dermal irritative / corrosive properties, dermal exposure has to be limited / minimized.C36-alkylenediamineis only used as intermediate in industrial settings where adequate PPE are applied, limiting direct dermal exposures. Consequently, skin contact in production and/or use is not likely. Testing by the dermal route is therefore not appropriate as stipulated in Annex IX, point 8.6.2, column 2 of REACH regulation (EC) 1907/2006.
Also available information suggests that dermal route is not the most sensitive route of exposure. Furthermore, following the severe irritating / corrosive properties of the substance, dermal testing should not be performedalso based on animal welfare grounds.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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