Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 208-307-3 | CAS number: 521-18-6
Endpoint summary
Administrative data
Description of key information
No acute toxicity studies were conducted with ZK 5145; read across approach with results of studies with androstanolone acetate (ZK 5180, CAS 1164-92-7):
Oral (Rat, GLP, not audited report; OECD 423): LD50 > 2000 mg/kg
[Schering AG, Report X235; 1997-08-15]
Dermal (Rat, GLP, not audited report; OECD 402): LD50 > 2000 mg/kg
[Schering AG, Report X296; 1998-09-24]
Key value for chemical safety assessment
Additional information
No acute toxicity studies were conducted with ZK 5145 (androstonolone). Results of one study conducted with an ester of androstonolone (androstonolone acetate, ZK 5180) are regarded as representative as most likely ester cleavage occurs in vivo after administration.
The single oral administration of ZK 5180 to 3 male and 3 female rats at a dose of 2000 mg/kg was tolerated without compound-related clinical findings. No substance-related macroscopic pathological signs were observed. The acute oral toxicity of ZK 5180 in rats is above 2000 mg/kg body weight. [Schering AG, Report No X235; 1997 -08 -15]
The single dermal administration of ZK 5180 to 3 male and 3 female rats at a dose of 2000 mg/kg was tolerated without any compound-related clinical or macroscopic pathological signs. The acute dermal toxicity of ZK 5180 in rats is above 2000 mg/kg body weight. [Schering AG, Report X296; 1998-09-24]
Justification for classification or non-classification
Since LD50 > 2000 mg/kg after oral administration there is no classification required according to Directive 67/548/EEC and Regulation (EC) 1272/2008 (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
