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EC number: 213-367-9 | CAS number: 939-97-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study report which meets basic scientific principles.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Groups of rats are gavaged daily with graduated doses of the test article for 5 consecutive days. For 24 hours, urine is collected after the last application of the compound. Urinary metabolites are detected by appropriate method (GC)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-tert-butylbenzaldehyde
- EC Number:
- 213-367-9
- EC Name:
- 4-tert-butylbenzaldehyde
- Cas Number:
- 939-97-9
- Molecular formula:
- C11H14O
- IUPAC Name:
- 4-tert-butylbenzaldehyde
- Details on test material:
- - Name of test material (as cited in study report): p-tert-butylbenzaldehyde
- Analytical purity: no data given
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- other: SPF albino
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: rape oil
- Duration and frequency of treatment / exposure:
- 5 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 12.5 and 50 mg/kg bw
- No. of animals per sex per dose / concentration:
- - Control: 4 male animals
- Dosed groups: 8 males/dose - Control animals:
- yes
- Details on study design:
- The urine samples were acidified with 37 % hydrochloric acid to pH 1-2 and extracted with ethylacetate using pre-packed extraction columns according to the procedure recommended by the manufacturer (Extrelut, Merck No. 11737/8).
After evaporation of the extraction solvent the residue was dissolved in 5 ml ethylacetate/methanol (4:1).
0.5 ml of the ethylacetate/methanol extract was evaporated to dryness, taken up in 200 µl DMF and methylated by heating with 200 µl DMF-DMA (Fluka) for 15 min at 90 °C.
0.5 ml of the ethylacetate/methanol extract was evaporated to dryness and heated with 1 ml acetic anhydride for 5 min at 95 °C in order to transform hippuric acid and TBHA into the corresponding molecules.
For GC analysis 1 µl of the reaction mixture was injected without further treatment. For GC reference pure TBBA was methylated with DMF-DMA. - Details on dosing and sampling:
- METABOLITE CHARACTERISATION STUDIES
- Tissues and body fluids sampled: urine
- Time and frequency of sampling: 24 h urine was collected after the last application of the test material
- From how many animals: no data given
- Method type for identification: GC-MS
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- p-Tert-butylbenzoic acid (TBBA) was identified as metabolite in the 24 hours urine in rats treated with p-tert-butylbenzaldehyde (TBB), but not the secondary metabolite p-tert-butylhippuric acid.
Any other information on results incl. tables
dose level weight of rats TBBA in last 24 h-urine
TBB (mg/kg) (g) (mg/l) (mg/kg)
----------------------------------------------------------
0 904 n.d. n.d.
12.5 mg/kg 1742 29 1.2
50.0 mg/kg 1578 235 12.7
n.d. = not detectable
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.