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EC number: 210-890-4 | CAS number: 625-36-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The test substance was concluded to be corrosive to the skin and causing irreversible damage to the eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, non guideline study, available as unpublished report, restrictions in design and/or reporting but otherwise adequate for assessment.
- Principles of method if other than guideline:
- The test substance was applied to white Vienna rabbits for 1 min, 5 min, 15 min and 20 h under occlusive conditions. The skin was left intact. Animals were observed for 8 days and skin changes were observed on working days. Findings were recorded after 24 hours and at the end of the observation period. Findings were graded as described in OECD test guideline 404.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.47 and 2.8 kg - Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animals
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): ca. 0.5 mL - Duration of treatment / exposure:
- 1, 5, 15 minutes and 20 hours
- Observation period:
- 8 days
- Number of animals:
- 2
- Details on study design:
- TEST SITE
- % coverage: 2.5 x 2.5 cm
REMOVAL OF TEST SUBSTANCE
- Washing: Lutrol:water (1:1)
SCORING SYSTEM: equivalent to the scoring system described in OECD 404 - Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24 hour
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: 1 minute exposure
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24 hour
- Score:
- 2
- Max. score:
- 4
- Remarks on result:
- other: 1 minute exposure. Slight scaling at day 8
- Irritation parameter:
- edema score
- Basis:
- animal: #1 and #2
- Time point:
- other: 24 hour
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: 1 minute exposure
- Irritation parameter:
- erythema score
- Basis:
- animal: #1 and #2
- Time point:
- other: 24 hour
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days.
- Remarks on result:
- other: 5 minutes exposure. Effect observed arround test-patch. Necrosis was observed within 24 hour.
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24 hour
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: 5 minutes exposure
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 24 hour
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: 5 minute exposure
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24 hour
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: 15 minutes exposure. Effect observed arround test-patch. Necrosis was observed within 24 hour.
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24 hour
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: 15 minutes exposure. Necrosis was observed within 24 hour.
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24 hour
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: 15 minutes exposure
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 24 hour
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: 15 minutes exposure
- Irritation parameter:
- erythema score
- Basis:
- animal: #1 and #2
- Time point:
- other: 24 hour
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: 20 hour exposure. Effect observed arround test-patch. Necrosis was observed within 24 hour.
- Irritation parameter:
- edema score
- Basis:
- animal: #1 and #2
- Time point:
- other: 24 hour
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: 20 hour exposure
- Irritant / corrosive response data:
- Full thickness necrosis of the skin was observed after exposure for 5 and 15 minutes as well as after 20 hours at the end of the observation period.
Necrosis was already observed at the 24 h reading (5 and 15 minutes, 20 hours).
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, non guideline study, available as unpublished report, restrictions in design and/or reporting but otherwise adequate for assessment.
- Principles of method if other than guideline:
- The test substance (0.05 mL) was applied to the conjunctival sac of white Vienna rabbits. The non-treated adjacent eye served as control, to which NaCl was applied. The animals were observed several times on the treatment day and 8 days afterwards, and findings were recorded on working days. The eyes were not washed out after 24 hours after substance application. Findings were graded as described in OECD test guideline 405.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.05 and 2.13 kg - Vehicle:
- unchanged (no vehicle)
- Controls:
- other: eye of the same animals treated with NaCl
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.05 mL - Duration of treatment / exposure:
- single application
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- SCORING SYSTEM: equivalent to the scoring system described in OECD 405 guideline.
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: #1 and #2
- Time point:
- other: 24 hours
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: Severe chemical burns and corneal opacity was observed throughout the study
- Irritation parameter:
- chemosis score
- Basis:
- animal: #1 and #2
- Time point:
- other: 24 hour
- Score:
- 0
- Max. score:
- 3
- Irritant / corrosive response data:
- Within one hour after application the first signs of corrosion were visible in combination with slight edema. Within 24 hours corrosion was observed. The tissue underneath the eye was severely damaged. After 8 days corrosion in combination with strong supperation.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
In a skin irriation/corrosion test, the test substance was applied to two white Vienna rabbits for 1 min, 5 min, 15 min and 20 h under occlusive conditions (1968; RL2). The skin was left intact. Animals were observed for 8 days and skin changes were observed on working days. Findings were recorded after 24 hours and at the end of the observation period. Findings were graded as described in OECD test guideline 404. Full thickness necrosis of the skin was observed after exposure for 5 and 15 minutes as well as after 20 hours at the end of the observation period. Necrosis was already observed at the 24 h reading (5 and 15 minutes, 20 hours). Even though necrosis was not observed following one minute application, it cannot be rules out that 3 minutes applications does not induce necrosis. Hence, as a worst case assumption, the substance is considered Category 1A.
Eye irritation
In a eye irritation/corrosion test, the test substance (0.05 mL) was applied to the conjunctival sac of two white Vienna rabbits (1968; RL2). The non-treated adjacent eye served as control, to which NaCl was applied. The animals were observed several times on the treatment day and 8 days afterwards, and findings were recorded on working days. The eyes were not washed out after 24 hours after substance application. Findings were graded as described in OECD test guideline 405. Within one hour after application the first signs of corrosion were visible in combination with slight edema. Within 24 hours corrosion was observed. The tissue underneath the eye was severely damaged. After 8 days corrosion in combination with strong supperation was observed.
Justification for classification or non-classification
Based on the severity and irreversibility of the observed effects, the test substance is classified as Skin corrosive category 1A, H314: Causes severe skin burns and eye damage in accordance with EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.
Because severe eye effects were observed after ocular application, the test substance has to be classified as Eye damage 1: H318: Causes serious eye damage in accordance with EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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