Registration Dossier
Registration Dossier
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EC number: 402-860-6 | CAS number: 110553-27-0 CG 25-1320; IRGANOX 1520; TK 12229/1
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data provided by ECHA - information from migrated NONS file as per inquiry 06-0000021296-70-0000.
Data source
Reference
- Reference Type:
- other: body responsible for the test
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: (Micronucleus test) Annex V, B12
- GLP compliance:
- yes
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- 4,6-bis(octylthiomethyl)-o-cresol
- EC Number:
- 402-860-6
- EC Name:
- 4,6-bis(octylthiomethyl)-o-cresol
- Cas Number:
- 110553-27-0
- Molecular formula:
- C25H44OS2
- IUPAC Name:
- 4,6-bis(octylthiomethyl)-o-cresol
Constituent 1
Test animals
- Species:
- hamster, Chinese
- Strain:
- other: random outbred strain
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Duration of treatment / exposure:
- 16, 24, 48 h
- Frequency of treatment:
- no data
- Post exposure period:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
5000 mg/kg
Basis:
no data
- No. of animals per sex per dose:
- Male: 5000 mg/kg; no of animals: 8; sacrifice time: 16 hours
Male: 5000 mg/kg; no of animals: 8; sacrifice time: 24 hours
Male: 5000 mg/kg; no of animals: 8; sacrifice time: 48 hours
Female: 5000 mg/kg; no of animals: 8; sacrifice time: 16 hours
Female: 5000 mg/kg; no of animals: 8; sacrifice time: 24 hours
Female: 5000 mg/kg; no of animals: 8; sacrifice time: 48 hours - Control animals:
- not specified
- Positive control(s):
- no data
Examinations
- Details of tissue and slide preparation:
- no data
- Statistics:
- no data
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- yes
- Remarks:
- Doses producing toxicity >5000 mg/kg
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Additional information on results:
- No evidence of mutagenic effects in Chinese hamster under the conditions of this experiment.
Any other information on results incl. tables
no data
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
The test substance is not mutagenic in the in vivo micronucleus test under the applied experimental conditions.
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