Registration Dossier
Registration Dossier
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EC number: 402-860-6 | CAS number: 110553-27-0 CG 25-1320; IRGANOX 1520; TK 12229/1
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: theoretical approach
- Adequacy of study:
- key study
- Study period:
- July 2011
- Reliability:
- other: not applicable
- Rationale for reliability incl. deficiencies:
- other: Study is based on expert judgment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
- Objective of study:
- toxicokinetics
- Principles of method if other than guideline:
- A theoretical approach of the toxicokinetic properties of the substance based on the available physico-chemical properties and toxicological data.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4,6-bis(octylthiomethyl)-o-cresol
- EC Number:
- 402-860-6
- EC Name:
- 4,6-bis(octylthiomethyl)-o-cresol
- Cas Number:
- 110553-27-0
- Molecular formula:
- C25H44OS2
- IUPAC Name:
- 4,6-bis(octylthiomethyl)-o-cresol
Constituent 1
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Only limited data has been provided by ECHA and it is difficult to make a full toxicokinetic assessment. In accordance with the Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.7C paragraph R.7.12 (Endpoint specific Guidance), having molecular weight of 424 g/mol and a low solubility in water of < 2 mg/L, the substance is not favorably for penetration across biological membranes and absorption into tissues.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): bioaccumulation potential cannot be judged based on study results
For risk assessment purposes the following absorption factors were derived:
oral absorption factor: 50%
dermal absorption factor: 50%
inhalation absorption factor: 100%
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